LEONARDI, AMEDEO,MOTTA, GIANNI,RIVA, CARLO,POGGESI, ELENA,GRAZIANI, DAVIDE,LONGHI, MATTEO MARCO
申请号：
ES08785292
公开号：
ES2380165T3
申请日:
2008.08.01
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Compounds presenting the general formula I ** Formula ** in which Z represents a group of formula -C≡C-R2 or -CH = CH-R2； R1 represents * a hydrogen or halogen atom, or * a hydroxy, cyano, C1-C6 alkyl, C1-C6 alkylcarbonyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, C1-C6 alkylcarbonyloxy, C1-C6 alkoxycarbonyloxy, C1-C6 alkylthio -C6, di- (C1-C6 alkyl) -amino or C3-C14 cycloalkyl； R2 represents * an optionally substituted monocyclic or bicyclic C1-C9 heterocyclic group comprising between 1 and 3 heteroatoms selected from nitrogen, oxygen and sulfur, * an optionally substituted monocyclic, bicyclic or tricyclic C6-C14 aryl group, * a C1-alkyl group -C6 optionally substituted, * an optionally substituted C2-C6 alkenyl group, or * an optionally substituted C3-C6 cycloalkyl group, or R2 represents a -C (O) -R2A group in which R2A is defined as R2 above； R3 represents * a hydrogen atom, * an optionally substituted C1-C6 alkyl group, * an optionally substituted monocyclic, bicyclic or tricyclic C1-C14 alkyl group comprising between 1 and 3 heteroatoms selected from nitrogen, oxygen and sulfur, * a optionally substituted monocyclic, bicyclic or tricyclic C6-C14 aryl group, * an optionally substituted C3-C6 cycloalkyl group, or * an optionally substituted C3-C6 cycloalkenyl group, Y represents a group of formula -C (O) -, -C ( S) -, -NH-C (O) -, -N (C1-C6 alkyl) -C (O) -, - OC (O) -, -NH-C (S) -, - N (C1- alkyl C6) -C (S) -, -OC (S) - or -SO2- or is not present. m is 0, 1 or 2； n is 0, 1 or 2； the substituents of each group being optionally substituted * a halogen atom or an oxo, nitro, cyano, hydroxy, carbamoyl, C1-C6 alkylsulfonyl, C1-C6 alkylthio, C1-C6 alkylcarbonyl or (C1-C6) alkylcarbonyl or a group of the formula -NR * R * in which each R * independently represents a hydrogen atom or a C1-C6 alkyl group, C1-C6 alkylcarbonyl, phenyl or benzyl, or * a C1-C6 alkyl group, C2 alkenyl C6, C2-C6 alkynyl or C1-C6 alkoxy, each of which may optionally have between 1 and 8 substituents
