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Carboxylic acid compound
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
TODA, NARIHIRO,YOSHIDA, MASAO,TAKANO, RIEKO,INOUE, MASAHIRO,HONDA, TAKESHI,MATSUMOTO, KOJI,NAKASHIMA, RYUTARO
申请号:
ES09770128
公开号:
ES2516716T3
申请日:
2009.06.23
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of the following general formula (I), or a pharmacologically acceptable salt thereof: ** Formula ** in which X represents>; = C (R5) - or>; = N-; And represents -O-; L represents a C1-C3 alkylene group optionally substituted with a halogen atom, a C1-C3 haloalkyl group or a C1-C3 alkyl group, or a bond; M represents a C3-C10 cycloalkyl group (the cycloalkyl group being optionally fused to a phenyl group or a 4- to 10-membered heterocyclic ring containing 1 to 3 heteroatoms that can be the same or different and are selected from nitrogen, oxygen and sulfur , and optionally substituted with 1 to 5 substituents selected from the substituent group a), a C6-C10 aryl group (the aryl group being optionally substituted with 1 to 5 groups selected from the substituent group a), or a heterocyclic group of 4 to 10 members containing 1 to 3 heteroatoms that may be the same or different and are selected from nitrogen, oxygen and sulfur (the heterocyclic group being optionally substituted with 1 to 5 substituents selected from the substituent group a); R1 represents an ethyl group; R2, R3, R4, and R5 each represent a hydrogen atom; and the substituent group a includes a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C1-C6 hydroxyalkyl group (the hydroxyalkyl group being optionally substituted with a C1-C6 alkyl group), an alkoxy group C1-C6 C1-C6 alkyl, a C1-C6 aminoalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group, a C6-C10 aryloxy group, a C1-C6 alkylthio group, a carboxy group, an alkoxycarbonyl group C1-C6, a hydroxy group, a formyl group, a C1-C6 haloalkyl carbonyl, methoxyacetyl or C1-C6 aliphatic acyl group, an amino group, a C1-C6 alkylamino group, a C3-C10 cycloalkylamino group, a C1 dialkylamino group -C6, a C1-C6 alkoxyamino group, a formylamino group, a C1-C6 haloalkylcarbonylamino, methoxyacetylamino or C1-C6 aliphatic acylamino group (the aliphatic C1-C6 acylamino group being optionally substituted with 1 to 3 halogen atoms),
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