CARSON, Dennis A.,TAKABAYASHI, Kenji,COTTAM, Howard B.,CHAN, Michael,WU, Christina C. N.
申请号：
ES06813535
公开号：
ES2577514T3
申请日:
2006.08.21
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound of formula (IA): ** Formula ** where X1 is -O-, -S-, or -NRc-； Rc being hydrogen, (C1-10) alkyl or (C1-10) alkyl substituted with (C3-6) cycloalkyl, or Rc and R1, together with the nitrogen atom, can form a heterocyclic ring or a substituted heterocyclic ring, being the substituents hydroxy, C 1-6 alkyl, hydroxy C 1-6 alkylene, C 1-6 alkoxy, C 1-6 alkoxy C 1-6 alkylene, amino, cyano, halogen or aryl； R1 is hydrogen, (C1-C10) alkyl, substituted (C1-C10) alkyl, substituted (C6-10) aryl or substituted (C6-10) aryl, heterocyclyl (C5-9), heterocyclyl (C5-9) substituted； the substituents of the groups being alkyl, aryl or heterocyclyl hydroxy, (C1-6) alkyl, hydroxy-C1-6 alkylene, (C1-6) alkoxy, (C3-6) cycloalkyl, (C1-6) alkoxy - (C1-6) alkylene, amino, cyano, halogen or aryl； each R2 is independently hydrogen, -OH, (C1-C6) alkyl, substituted (C1-C6) alkyl, (C1-C6) alkoxy, substituted (C1-C6) alkoxy, -C (O) -C1-C6 alkyl (alkanoyl), -C (O) -substituted (C1-C6) alkyl, -C (O) -aryl (C6-C10) (aroyl), -C (O) -aryl (C6-C10) substituted, -C (O) OH (carboxyl), -C (O) O-C1-C6 alkyl (alkoxycarbonyl), -C (O) O-C1-C6 alkyl substituted, -NRaRb, -C (O) NRaRb ( carbamoyl), -C (O) substituted NRaRb, halo, nitro, or cyano； substituents being the alkyl, aryl or heterocyclyl hydroxy, (C1-6), hydroxyalkylene (C1-6), alkoxy (C1-6) groups ), cycloalkyl (C3-6), alkoxy (C1-6) alkylene (C1-6), amino, cyano, halogen or aryl； and n is 1, 2, 3 or 4； each Ra and Rb is independently hydrogen, alkyl ( C1-C6), cycloalkyl (C3-C8), alkoxy (C1-C6), haloalkyl (C1-C6), cycloalkyl (C3-C8) alkyl (C1-C6), alkanoyl (C1-C6), hydroxyalkyl (C1- C6), aryl, aryl (C1-C6) alkyl, Het, Het-alkyl (C1-C6) or alkoxycarbonyl (C1-C6)； X2 is a bond or a linking group； and the auxiliary group r R3 is a protein or a peptide； or a pharmaceutically acceptable salt thereof.Compuesto de fórmula (IA):**Fórmula** donde X1 es -O-, -S-, o -NRc-； siendo Rc hidrógeno, alquilo(C1-10) o alquilo(C1-10) sustituido con cicloalquilo(C3-
