您的位置: 首页 > 农业专利 > 详情页

Poly (ADP-ribose) polymerase dihydropyridophthalazinone inhibitors (PARP)
专利权人:
BIOMARIN PHARMACEUTICAL INC.;BIOMARIN PHARM INC
发明人:
WANG, BING,CHU, DANIEL,WANG BING,CHU DANIEL
申请号:
ES09805360
公开号:
ES2466565T3
申请日:
2009.07.27
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of the formula (I): ** Formula ** wherein: 5 Y and Z are each independently selected from the group consisting of: a) an aryl group optionally substituted with 1, 2 or 3 R6 ; b) a heteroaryl group optionally substituted with 1, 2 or 3 R6; and c) a substituent independently selected from the group consisting of hydrogen, C2-C10 alkenyl, C1-C10 alkoxy, C1-C10 alkoxy-C1-C10 alkyl, C1-C10 alkoxy-carbonyl-C1-C10 alkyl alkyl C1-C10, C2-C10 alkynyl, aryl-C1-C10 alkyl, C3-C10 cycloalkyl, C3-C10 cycloalkyl-C1-C10 alkyl, C1-C10 haloalkyl, C1-C10 hydroxyalkylene, oxo, heterocycloalkyl, heterocycloalkyl-C1-alkyl C10, C1-C10 alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl C1-C10 alkyl sulfonyl, arylsulfonyl, heteroarylsulfonyl, (NRARB) C1-C10 alkylene, (NRARB) carbonyl C1-C10 alkylene, (NRARB) sulfonyl and (NRARB ) sulfonyl-C1-C10 alkylene; R1, R2 and R3 are each independently selected from the group consisting of hydrogen, halogen, C2-C10 alkenyl, C1-C10 alkoxy, C1-C10 alkoxycarbonyl, C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkynyl, cyano, C1-C10 haloalkoxy, C1-C10 haloalkyl, hydroxyl, C1-C10 hydroxyalkylene, nitro, NRARB, NRARB-C1-C10 alkylene and (NRARB) carbonyl; A and B are each independently selected from hydrogen, Br, Cl, F, I, OH, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C10 alkoxy and C1-C10 alkoxy-C1-C10 alkyl, wherein C1-C6 alkyl, C3-C8 cycloalkyl, C1-C10 alkoxy and C1-C10 alkoxy-C1-C10 alkyl are optionally substituted with at least one substituent selected from OH, NO2, CN, Br, Cl, F, I, C1-C6 alkyl and C3-C8 cycloalkyl, wherein B is not OH; each R6 is selected from OH, NO2, CN, Br, Cl, F, I, C1-C6 alkyl, C3-C8 cycloalkyl, C2-C8 heterocycloalkyl; C2-C6 alkenyl, C1-C10 alkoxy, C1-C10 alkoxy-C1-C10 alkyl, C1-C10 alkoxycarbonyl, C1-C10 alkoxy-C1-C10 alkyl, C2-C6 alkynyl, aryl, aryl-C1 alkyl -C10, C3-C8 cycloalkyl-C1-C10 alkyl, C1-C10 haloalkoxy, C1-C10 haloalkyl, C1-C10 hydroxyalkylene, oxo, heteroaryl, heteroaryl-C1-C10 alkoxy, heteroaryloxy, heteroarylthio, hetero
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充