The present invention is a compound of formula (I), wherein R 1 is C 1 -C 3 alkyl optionally substituted with F, C 3 -C 6 cycloalkyl, C 1 -C 3 alkoxy； and X is a bond Or C1 -C3 alkylene optionally substituted with OH, ONO, ONO2； R2 is H, OH, ONO, ONO2, C (O) OH, C (O) OC1-C3 alkyl, CHO, CN, C1-C3 alkoxy, OC (O) H, OC (O) -C1-C3 alkyl, C (O) N (R6) OR7, OC1-C3 alkylene-C (O) OH, OC1-C3 alkylene-C (O ) OC1-C3 alkyl, OC1-C3 alkylene-C (O) N (R6) OR7, S (OO-2) C1-C3 alkyl, CR8 = N-OR9, CR8 = N-NR10R11, CR8 = NR12 Is CR8 = N-ONO2； R3 is optionally F, OH, ONO, ONO2, C1-C3 alkoxy, C1-C6 alkyl substituted with C3-C6 cycloalkyl； C3-C6 cycloalkyl, C2-C6 C6 alkenyl, C2 to C6 alkynyl； R4 is optionally C3 to C6 cycloalkyl, C1 to C6 alkoxy, F, ONO, C1 to C6 alkyl substituted with ONO2； C2 to C6 alkenyl, C2 to C6 alkynyl R5 is H, SO2 NR13 R14, NHSO2 NR13 R14； R6 is H or C1 to C3 alkyl； R7 is H, C1 to C3 alkyl, C1 to C3 alkyl, C1 to C3 alkoxy, phenyl, benzyl C 1 -C 3 alkyl or heterocycle substituted by R.sup.8 is H, CH.sub.3, or C.sub.2 H.sub.5； R.sup.9: H, optionally OH, ONO, ONO.sup.2, benzyl, or said heterocyclic ring is independently optionally substituted with C.sub.1-C.sub.3 alkyl, F； CN, COOH, COOC1-C3 alkyl, C1-C3 alkoxy, OC (O) H, OC (O) -C1-C3 alkyl, C (O) N (R6) OR7, OC1-C3 alkylene-C (O) OH , OC1-C3 alkylene-C (O) OC1-C3 alkyl, OC1-C3 alkylene-C (O) N (R6) OR7, C1-C3 alkyl substituted with S (O0-2) C1-C3 alkyl, R10 and R11 are each independently H, optionally OH, ONO, ONO2, CN, COOH, COOC1 to C3, C1 to C3 alkoxy, OC (O) H, OC (O) -C1-C3 alkyl, C (O) N (R6) OR7, OC1-C3 alkylene-C (O) OH, OC1-C3 alkylene-C (O) OC1-C3 alkyl, OC1-C3 alkylene- C (O) N (R6) OR7, S (O0-2) C1-C3 alkyl substituted with C1-C3 alkyl； or form a heterocycle with the nitrogen atom bonded to itself, preferably , Wherein said heterocycle is selected from aziridine, azetidine, pyrollidine, piperidine, morpholine, piperazine and homopiperazine, said heterocycle is optionally substituted with C1-C3 alkyl；
