UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人:
STELLA, NEPHI,KLINE, TONI
申请号：
ES11749677
公开号：
ES2530629T3
申请日:
2011.08.22
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula: ** Formula ** or pharmaceutically acceptable salts, wherein X is CH or N； R11 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 haloalkoxy, halogen, -NO2, -CN, -OR15, -SR15 , -C (O) R15, -NHC (O) R15, -C (O) OR15, -OC (O) R15, -NR16R17, -C (O) NR16R17, -NHR15C (O) NR16R17, -SO2NR16R17, alkylaryl , cycloalkyl, heterocyclyl, or heteroaryl, each is optionally substituted with one to four R20； R12 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6haloalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 haloalkoxy, halogen, -NO2, -CN, -OR15, - SR15, -C (O) R15, -NHC (O) R15, -C (O) OR15, -OC (O) R15, -NR16R17, -C (O) NR16R17, -NHR15C (O) NR16R17, -SO2NR16R17, alkylaryl, cycloalkyl, heterocyclyl, or heteroaryl, each is optionally substituted with one to four R20； R14 and R13 taken together with the atoms to which they are attached form a 5, 6, or 7-membered heterocyclyl group optionally substituted with one to four R20； R15, R16, and R17 are independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, halogen, hydroxy, aryl, alkylaryl, cycloalkyl, heterocyclyl, or heteroaryl, each optionally substituted with one to four R20； R18 and R19 are each independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 hydroxyalkyl, halogen, -NO2, - CN, -OR15, -SR15, -C (O) R15, -NHC (O) R15, -C (O) OR15, -OC (O) R15, -NR16R17, -C (O) NR16R17, -NHR15C (O ) NR16R17, -SO2NR16R17, alkylaryl, cycloalkyl, heterocyclyl, or heteroaryl, each is optionally substituted with one to four R20, R20 is halogen, -CN, -OH, -NO2, -NH2, -NH (C1-C6 alkyl) , -N (C1-C6alkyl) 2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, - CO2H, -CO2 (C1-C6 alkyl), -SO2 (C1-C6 alkyl), -CONH2, -CONH (C1-C6alkyl), -CON (C1-C6 alkyl) 2, -CON (H) OH, -NHCO (C1-C6 alkyl), or -NHCO2 (C1-C6 alkyl)； andUn compuesto de la fórmula
