FLYGARE, JOHN,FAIRBROTHER, WAYNE,KETELTAS, STEPHEN FRANZ,COHEN, FREDERICK,TSUI, VICKIE HSIAO-WEI
申请号：
AU2005228950
公开号：
AU2005228950B2
申请日:
2005.03.22
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention provides novel inhibitors of IAP that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula (I) in which X and X are independently O or S； L is a bond or -C(X)-, -C(X)NR, -C(X)O- wherein X is O or S and R is H or R； R is alkyl, a carbocycle, carbocycle-substituted alkyl, a heterocycle or heterocycle-substituted alkyl, wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, haloalkyl, alkoxy, alkylsulfonyl, amino, nitro, aryl and heteroaryl； R is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, a heterocycle or heterocyclylalkyl； R is H or alkyl； R and R are independently H, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, or heteroaralkyl wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, alkoxy, amino and nitro； R, and R are each independently H or alkyl； R is H or alkyl； and salts and solvates thereof.
