CHELLAPPAN Shila K. (US),ЧЕЛЛАППАН Шила К. (US),KHORMAN Robert E. (US),ХОРМАН Роберт Е. (US),SHULMAN Inna (US),ШУЛЬМАН Инна (US),CHELLAPPAN Shila K.,ЧЕЛЛАППАН Шила К.,KHORMAN Robert E.,ХОРМАН Роберт Е.,SHULMAN Inna,ШУЛЬМАН Инна
申请号：
RU2015138798
公开号：
RU0002637946C2
申请日:
2014.03.14
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: pharmacology.SUBSTANCE: invention relates to a compound that has formula I , or its pharmaceutically acceptable salts, which can be used to modulate the expression of exogenous gene. In formula I, R1 and R2 each is independently selected from the group consisting of hydrogen, C1-4 alkyl and C1-4 haloalkyl； R3 is selected from the group consisting of hydrogen, C1-4 alkyl, C1-4 haloalkyl and C6-14 aryl； R4 is selected from the group consisting of R4-1 , R4-2 and R4-5 X1 is selected from the group consisting of -O- and -N(R8a)-； Y1 is -(CR9aR9b)m-； Z1 is selected from the group consisting of -O- and -N(R8b)-, or Z1 absent； R6a is selected from the group consisting of hydroxy, C1-4 alkyl and C1-4 alkoxy； or R6a forms an amino acid adduct； R7a and R7b each is independently selected from the group consisting of hydrogen, halogen and C1-4 alkyl； R8a and R8b each is independently selected from the group consisting of hydrogen and C1-4 alkyl； R9a and R9b each is independently selected from the group consisting of hydrogen and C1-4 alkyl； m is 1, 2, 3 or 4； X2 is -O-； Y2 is -(CR9cR9d)n-； Z2 absent； R6b is selected from the group consisting of hydroxy, C1-4 alkyl and C1-4 alkoxy； or R6b forms an amino acid adduct； R7c and R7d each is independently selected from the group consisting of hydrogen, halogen and C1-4 alkyl； R9c and R9d each is independently selected from the group consisting of hydrogen and C1-4 alkyl； n is 1, 2, 3 or 4； R10a is selected from the group consisting of hydrogen and -(CR11aR11b)o-B(R12a) (R12b)； R10b, R10c and R10d each is independently selected from the group consisting of hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy C1-4 alkyl, C1-4 haloalkoxy, C1-4 hydroxyalkyl and C1-4 alkoxy； R11a and R11b each is independently selected from the group consisting of hydrogen and C1-4 alkyl； R12a and R12b are selected from the group consisting of hydroxy and C1-4 alkoxy； or R12a and R12b together form a joint -O(CR13aR13b)pO-； or -B (R
