BRAD BUCKMAN,JOHN B. NICHOLAS,JOHNNIE Y. RAMPHAL,KUMARASWAMY EMAYAN,SCOTT D. SEIWERT
申请号：
ARP130103530
公开号：
AR092742A1
申请日:
2013.09.30
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: a compound characterized by the structure of formula (1) or one of its pharmaceutically acceptable salts,In which: r u00b9 is selected from the Group comprising Halogen, - CN, - C (o) - r u2078, so u2082r u00b9 u2076 alkyl, optionally substituted by one or more c u2081 u208b u2086 r u2074,Alquenilo c u2082 u208b u2086 optionally substituted by one or more r u2074, alquinilo c u2082 u208b u2086 optionally substituted by one or more r u2074, c u2086 u208b u2081 u2080 aryl optionally substituted by one or more r u2074,A heteroaryl 5-10 members optionally substituted by one or more r u2074, carbociclilo c u2083 u208b u2081 u2080 optionally substituted by one or more r u2074,And heterociclilo 3 - 10 members optionally substituted by one or more r u2074； R u00b2 is selected from the Group comprising Halogen, - CN, - - - nr u2076r u2077 sr u2075 or u2075,,,And - C (o) r u2078； r u00b3 is selected from the group consisting of hydrogen, - (ch u2082 u2099 - (aryl) c u2086 u208b u2081 u2080) - (ch u2082 u2099 - (heteroaryl) 5 - 10 members) - (ch u2082) u2099 - (carbociclilo c u2083 u208b u2081 u2080)- (ch u2082) and u2099 (heterociclilo - 3 - 10 members), each optionally substituted by one or more r u2079 r u2074 independently； each is selected among the Group comprising Halogen, - CN, - Oh, - C (o) r u2078,- so u2082r u00b9 u2076, c u2081 u208b u2086 optionally substituted alkyl, optionally substituted alquenilo c u2082 u208b u2086, alquinilo c u2082 u208b u2086 optionally replaced, c u2081 u208b u2086 alkoxy optionally substituted,C u2086 u208b u2081 u2080 aryl optionally substituted by one or more r u00b9 u00b9, aralquilo c u2087 u208b u2081 u2084 optionally substituted by one or more r u00b9 u00b9, heteroaryl 5-10 members optionally substituted by one or more r u00b9 u00b9,Two geminales Together or independently r u2074 are oxo r u2075 independently； each is selected among the Group comprising Hydrogen, optionally substituted alkyl c u2081 u208b u2086,Alquenil
