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HETEROLOGICAL IMMUNIZATION AGAINST THE AFRICAN CATARAL FEVER VIRUS IN PRIME BUST MODE
专利权人:
Вайет ЭлЭлСи (US)
发明人:
БАРТРАМ Дэвид Джеймс (GB)
申请号:
RU2012107823/15
公开号:
RU2012107823A
申请日:
2010.08.30
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of generating an antigen-specific immune response in a subject, comprising administering to the subject at least one dose of a first immunogenic composition comprising an African catarrhal fever virus, administering to the subject at least one dose of a second immunogenic composition containing an African catarrhal fever virus, wherein the first and second the immunogenic compositions are different and where the second immunogenic composition is administered after administration of the first immunogenic composition. 2. The method according to claim 1, where the virus of African catarrhal fever is a serotype 8.3. The method of claim 2, wherein the first immunogenic composition is BOVILIS BTV-8 and the second immunogenic composition is ZULVAC8 BOVIS. 4. The method of claim 2, wherein the first immunogenic composition is ZULVAC8 BOVIS and the second immunogenic composition is BOVILIS BTV-8.5. The method according to any one of claims 1 to 4, where at least one of the first and second immunogenic compositions is administered by a route selected from the group consisting of: intravenous, intradermal, subcutaneous, intramuscular, intraperitoneal, oral, rectal, intranasal, buccal and vaginal route of administration. 6. The method of claim 5, wherein the first immunogenic composition is administered using an intramuscular or subcutaneous route of administration. The method of claim 6, wherein the second immunogenic composition is administered using an intramuscular or subcutaneous route of administration. The method according to any one of claims 1 to 4, wherein the second immunogenic composition is administered no more than about 10 weeks after the administration of the first immunogenic composition. The method of claim 8, where the second immunogenic com1. Способ генерирования антиген-специфического иммунного ответа у субъекта, включающийвведение субъекту по меньшей мере одной дозы первой иммуногенной композиции, содержащей вирус африканской катаральной лихора
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