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Intravesical administration of apaziquon after transurethral resection in the treatment of cancer
专利权人:
СПЕКТРУМ ФАРМАСЬЮТИКАЛЗ; ИНК. (US)
发明人:
ЛЕНАЗ Луиджи (US),ЧОЛА Шанта (US),БИР Марио (US)
申请号:
RU2012157329/15
公开号:
RU2012157329A
申请日:
2012.12.26
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of preventing a malignant tumor, comprising administering a therapeutic composition comprising a therapeutic amount of apaziquon (EO9) within about 6 hours after transurethral resection of a bladder tumor (TUROMP). The method of claim 1, wherein said administration is an intravesical drip infusion. The method according to claim 1, wherein said administration is carried out within about 5 hours after TUROMP. The method according to claim 1, wherein said administration is carried out within about 4 hours after TUROMP. The method according to claim 1, wherein said administration is carried out within about 3 hours after TUROMP. The method according to claim 1, wherein said cancer is bladder cancer. The method according to claim 1, wherein said malignant tumor is non-invasive bladder cancer. The method of claim 1, wherein said malignant tumor is transitional bladder carcinoma of the bladder. The method according to claim 1, wherein said cancer is a stage of Ta or T1 according to the classification of TNM.10 The method according to claim 1, wherein said cancer is a histological degree of G1 or G2.11. The method according to claim 1, wherein said therapeutic composition comprises from about 1 mg to about 8 mg per dose of apaziquon. The method of claim 1, wherein said therapeutic composition comprises from about 2 mg to about 6 mg per dose of apaziquon. The method of claim 1, wherein said therapeutic composition comprises from about 3 mg to about 5 mg per dose of apaziquon. A method for preventing a malignant tumor, comprising the steps of: (a) executing1. Способ предотвращения злокачественной опухоли, включающий введение терапевтической композиции, содержащей терапевтическое количество апазиквона (EO9), в пределах приблизительно 6 ч после трансуретральной резекции опухоли мочевого пузыря (ТУРОМП).2. Способ по п.1, в котором указанным введением является внутрипузырное капельное вливание.3. Способ по п.1, в котором указанное введение проводят в пределах приблизи
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