AUGERI DAVID JOHN,BAGDANOFF JEFFREY THOMAS,CARSON KENNETH GORDON,ORAVECZ TAMAS,GILLERAN JOHN ANTHONY,BAUGH SIMON DAVID PETER,CARLSEN MARIANNE,HE WEI,SALOJIN KONSTANTIN,SUNG LEONARD
申请号：
ARP120100691
公开号：
AR085607A1
申请日:
2012.03.02
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
Compositions containing same and Methods of Use thereof in the treatment, management or prevention of disease or autoimmune or inflammatory disorders.Claim 1: a compound of the formula (1) or a pharmaceutically acceptable Salt thereof, wherein a is aryl or Heterocyclic 4 - 7 members； X is n or CH, Y1 and Y2 are each, independently, S, N or CH, provided that at least one and e Y2 is n or CH； each R1 is an inde Slope, A1A, nsopr1c (r1b), - (r1b) nsopn (r1c) 2 - (r1b) nnr1csopr1c,- (r1b) NC (o) n (r1c) 2 or (r1b) nnr1cc r1c (OR), or hidrocarbilo c1-12 optionally substituted or heterocarbilo 2 - 12 members, in which the substitution is optional, with one or more of A1A A1A； each is independently, amino, alkoxyl cyano Halo, carboxyl, hydroxyl, or r1b； each is, so Independent hidrocarbilo c1-12 optionally substituted with one or more of amino, alkoxyl,Cyano Halo or hydroxyl, carboxyl, r1c； each is independently Hydrogen or optionally substituted or hidrocarbilo c1-12 heterocarbilo 2 - 12 members, in which the substitution is optional, with one or more of amino, cyano Halo alkoxyl, hydroxyl, carboxyl, or R2 and R3 are taken together； S to form a Five Member heterocycle - 7, optionally substituted with one or more R3A,Or: R2 is Hydrogen or c1-4 alkyl； and R3 is Hydrogen or hidrocarbilo C1 - 12 or heterocarbilo 2 - 12 members, optionally substituted, in which is replaced with one or more Optional R3A R3A； each is independently, alkoxyl, carboxyl, amino, cyano, Halo, or hydroxyl is 0； K M is 0 OR 1； - 1； n is 0 OR 1； and P is 0 - 2； with the condition that R3 is Hydrogen when X is CHY1 Y2 is is CH, CH, and R2 is Hydrogen.Composiciones que los comprenden y métodos de uso de los mismos, en el tratamiento, manejo o prevención de enfermedades o trastornos inflamatorios o autoinmunes.Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptables del mismo, en donde: A es arilo o heterociclo de 4 - 7 miembros； X es N o CH； Y1 e Y2 son cada uno, de manera in
