CHAPPIE, Thomas,HELAL, Christopher,KORMOS, Bethany,TUTTLE, Jamison,VERHOEST, Patrick
申请号：
ES14727054
公开号：
ES2637816T3
申请日:
2014.04.23
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula: ** (See formula) ** or a pharmaceutically acceptable salt thereof, in which: A, together with X and the carbon atom to which it is attached, forms an aryl (C6-C10) or a 5 to 10-membered heteroaryl moiety, wherein said aryl or heteroaryl moiety is optionally substituted with up to 4 substituents, each independently selected from the group consisting of C3-C6 cycloalkyl, oxo, optionally substituted C1-C6 alkyl, C1- alkoxy Optionally substituted C6, hydroxy, cyano, halo, -NR5R6, -C (O) -NR5R6, -NH-C (O) R5, -C (O) -OR5, -alkyl (C1-C6) -cycloalkyl (C3- C6), a 4- to 6-membered heterocyclic moiety, phenyl, and benzyl； X is represented by N or C； R1 is represented by C1-C6 alkyl, (C6-C10) aryl or a 5- to 6-membered heterocyclic moiety, wherein said alkyl, aryl or heterocyclic moiety may be optionally substituted with up to 4 substituents, each independently selected from the group consisting of halogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, hydroxy, cyano, -NR5R6, -C (O) -NR5R6, -NH-C (O) R5, and -C (O) - OR5, each of R2 and R3 is independently represented by hydrogen, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 alkoxy； R4, if present, is optionally represented by up to 2 substituents, each independently selected from the group consisting of fluorine, hydroxy, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 alkoxy, and； each of R5 and R6 is optionally and independently represented by hydrogen or C1-C6 alkyl.Un compuesto de fórmula: **(Ver fórmula)** o una sal farmacéuticamente aceptable del mismo, en la que: A, junto con X y el átomo de carbono al que está unido, forma un arilo (C6-C10) o un resto heteroarilo de 5 a 10 miembros, en la que dicho resto arilo o heteroarilo está opcionalmente sustituido con hasta 4 sustituyentes, cada uno independientemente seleccionado del grupo que consiste en cicloalquilo C3-C6, oxo, alquilo C1-C6 opcionalmente sustituido, alcoxi C1-C6 opci
