ALLEN, JOHN GORDON,TIDWELL, MICHAEL WADE,VICTOR, FRANTZ,WILLIAMS, ANDREW CAERWYN,ZHANG, DEYI,BOYD, STEVEN ARMEN,CONWAY, RICHARD GERARD,DEO, ARUNDHATI S,LEE, WAI-MAN,SIEDEM, CHRISTOPHER STEPHEN,SINGH,
申请号：
ES12161584
公开号：
ES2468741T3
申请日:
2005.02.18
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of Formula I: in which: R1 is hydrogen； each R2, R3 and R4 is hydrogen； R5 is hydrogen； R6 is -S-L-R15； R7 is chlorine； R8 is hydrogen； R9 is hydrogen； R15 is Ph2 or Ar2, in which Ph2 and Ar2, when Ar2 is pyridyl, may optionally also be substituted with phenyl-CH>； = CH- or phenyl-CC-, said phenyl-CH>； = CH- and phenyl-CC being said - optionally further substituted in the phenyl moiety with 1 to 3 substituents independently selected from the group consisting of halo, cyano, -SCF3, (C1-C6) alkyl optionally further substituted with 1 to 6 fluoro substituents, and (C1-C6) alkoxy optionally further substituted with 1 to 6 fluoro substituents, and in which Ar2 may alternatively be optionally substituted with a substituent selected from the group consisting of cycloalkyl (C3-C7) -alkyl (C0-C7), Het1-alkyl (C0-C3), pyridyl-alkyl (C0-C3), and phenyl-alkyl (C0-C3), and optionally further substituted with a methyl substituent, -CF3, cyano or -SCF3, or with 1 to 2 halo substituents, said pyridyl (C0-C3) alkyl and phenyl (C0-C3) alkyl being optionally further substituted with 1-3 s independently selected usstituents of halo, -CH3, -OCH3, -CF3, -OCF3, -CN and -SCF3, and in which, when Ar2 is pyridyl, the pyridyl may alternatively be optionally substituted with R28R29N-C ( O) -, or (C1-C6) -C (O) alkyl - optionally substituted with 1 to 6 fluoro substituents, and may be optionally further substituted with a methyl substituent, -CF3, cyano, or -SCF3, or with 1 to 2 halo substituents, and in which, when Ar2 is thiazolyl, the thiazolyl may alternatively be optionally substituted with cycloalkyl (C3-C7) -alkyl (C0-C3) -NH-, and L is alkylene (C1- C6) branched or unbranched, except when R15 is -Ar2 linked by N to L, in which case L is branched or unbranched (C2-C6) alkylene, and when L is methylene or ethylene, L may be optionally substituted with gem -ethane or with 1 to 2 fluoro substituents, and when R15 is Ph2 or Ar2, it may alternatively be optionally substituted w
