LI, HONGBIN,YUAN, JUN,BAKTHAVATCHALAM, RAJAGOPAL,HODGETTS, KEVIN J.,CAPITOSTI, SCOTT M.,MAO, JIANMIN,WUSTROW, DAVID J.,GUO, QIN
申请号：
ES08796352
公开号：
ES2551095T3
申请日:
2008.07.21
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula: ** Formula ** or a pharmaceutically acceptable salt or hydrate, wherein: W is -C (>； = O) NR4-, -NR4C (>； = O) - or -NR4-NR4-C (>； = O) -； V is C1-C6 alkylene which is substituted with 0 to 4 substituents independently selected from: (i) C1-C4 alkyl, (C3-C8 cycloalkyl) - (C0-C2 alkyl) and phenyl- (C0-C2 alkyl)； (ii) substituents that are considered together with any of the intermediate carbon atoms, to form a 3-7 membered cycloalkyl or a 4-7 membered heterocycloalkyl ring； and (iii) substituents that are considered together with R4 and any of the intermediate atoms to form a 4- to 7-membered heterocycloalkyl； Y is 5 to 6 membered phenyl or heteroaryl, each of which is substituted with 0 to 3 substituents independently selected from hydroxy, halogen, cyano, amino, nitro, oxo, aminocarbonyl, aminosulfonyl, -COOH, C1-C6 alkyl , C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 halogenoalkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy, C2-C6 alkyl ether, C1-C6 alkanoyl, C1- alkylsulfonyl C6, (C3-C7 cycloalkyl) - (C0-C4 alkyl) and mono or di- (C1-C6 alkyl) amino； R2 represents 0 to 2 substituents independently selected from halogen, cyano, amino, nitro, aminocarbonyl, aminosulfonyl, -COOH, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 halogenoalkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy, C1-C6 alkanoyl, C2-C6 alkyl ether, (C3-C7 cycloalkyl) - (C0-C4 alkyl), mono or di- (C1-C6 alkyl) amino, C1-C6 alkylsulfonyl, C1-C6 alkanoylamino, mono or di- (C1-C6 alkyl) aminocarbonyl, mono or di- (C1-C6 alkyl) aminosulfonyl and (C1-C6 alkyl) sulfonylamino； each R4 hydrogen or C1-C4 alkyl； or: (i) each R5 is independently hydrogen, -COOH, C1-C6 alkyl or (C3-C7 cycloalkyl) - (C0-C4 alkyl), so that at least one R5 is not hydrogen； or (ii) both R5 moieties are considered together with the carbon atom to which they are attached to form a C3-C7 cycloalkyl； and RA is 5-6 membered phenyl or heteroaryl which
