TURNER, SEAN COLM,BAKKER, MARGARETHA HENRICA MARIA,HORNBERGER, WILFRIED,WOLTER, FALKO ERNST
申请号：
ES10710586
公开号：
ES2531410T3
申请日:
2010.03.26
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Heterocyclic compounds of the general formulas IA and IB ** Formula ** the stereoisomers, N-oxides, prodrugs, tautomers and / or physiologically tolerated acid addition salts thereof, where A is a saturated heterocyclic ring, linked to N, bicyclic or tricyclic of 6, 7, 8, 9, 10, 11, 12, 13 or 14 members containing a nitrogen atom and optionally 1, 2 or 3 additional heteroatoms or groups containing heteroatoms, selected from N, O, S, SO and SO2 as ring members and optionally bearing 1, 2, 3 or 4 R6 substituents； X1, X2, X3 and X4 are independently selected from each other from the group consisting of CR3 and N； X5, X6 and X7 are independently selected from each other from the group consisting of CR4 and N； with the proviso that at least one of X5, X6 and X7 is N； R1 is hydrogen or a hydrolysable group； R2 is hydrogen, OH or F； each R3 is independently selected from the group consisting of hydrogen, CN, NRaRb, OH, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C3-C7-halocycloalkyl, C2-C4-alkenyl , C2-C4-haloalkenyl, C1-C6-alkoxy, C1-C6-haloalkoxy, formyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, C1-C6-alkyl -NRaRb and an aromatic radical Ar, which is selected from the group consisting of phenyl and a 5- or 6-membered N or C heteroaromatic radical comprising a nitrogen atom and optionally 1, 2 or 3 additional heteroatoms independently selected from O, S and N as ring members, where Ar is unsubstituted or carries one or two radicals R7 and where Ar can also be linked by a CH2 group； each R4 is independently selected from the group consisting of hydrogen, CN, NRaRb, OH, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C3-C7-halocycloalkyl, C2-C4-alkenyl , C2-C4-haloalkenyl, C1-C6-alkoxy, C1-C6-haloalkoxy, formyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, C1-C6-alkyl -NRaRb and an aromatic radical Ar, which is selected from the group consisting of phe
