KLAUS, Stephen J.,LIN, Al Y.,NEFF, Thomas B.,WANG, Qingjian,GUENZLER-PUKALL, Volkmar,AREND, Michael P.,FLIPPIN, Lee A.
申请号：
ES10181796
公开号：
ES2686626T3
申请日:
2002.12.06
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound for use in the prevention or treatment of anemia associated with kidney disease in a subject, wherein the compound is a compound of formula (I): ** Formula ** wherein A is (C1-C4) -alkylene； B is -CO2H, -NH2, -NHSO2CF3, tetrazolyl, imidazolyl, 3-hydroxyisoxazolyl, -CONHCOR '", - CONHSOR"', CONHSO2R '' ', where R' '' is aryl, heteroaryl, (C3-C7) - cycloalkyl, or (C1-C4) -alkyl, optionally monosubstituted with (C6-C12) -aryl, heteroaryl, OH, SH, (C1-C4) -alkyl, (C1-C4) -alkoxy, (C1-C4) - thioalkyl, (C1-C4) -sulfinyl, (C1-C4) sulfonyl, CF3, Cl, Br, F, I, NO2, -COOH, (C2-C5) -carbonyl, NH2, mono- (C1-C4-alkyl ) - amino, di- (C1-C4-alkyl) -amino, or (C1-C4)-perfluoroalkyl； or wherein B is a CO2-G carboxyl radical, where G is a radical of a G-OH alcohol in which G is selected from a (C1-C20) -alkyl radical, a (C3-C8) cycloalkyl radical, radical (C2-C20) -alkenyl, radical (C3-C8) -cycloalkenyl, retinyl radical, radical (C2-C20) - alkynyl, radical (C4-C20) -alkeninyl, where alkenyl, cycloalkenyl, alkynyl, and alkenyl radicals contain one or more multiple links； (C6-C16) -carbocyclic radical, aralkyl (C7-C16) -carbocyclic radical, heteroaryl radical, or heteroaralkyl radical, wherein a heteroaryl radical or heteroaryl moiety of a heteroaralkyl radical contains 5 or 6 ring atoms； and wherein the radicals defined for G are substituted by one or more of hydroxyl, halogen, cyano, trifluoromethyl, nitro, carboxyl, (C1-C12) -alkyl, (C3-C8) -cycloalkyl, (C5-C8) -cycloalkenyl , (C6-C12) -aryl, (C7-C16) -aralkyl, (C2-C12) -alkenyl, (C2-C12) -alkynyl, (C1-C12) -alkoxy, (C1-C12) -alkoxy- ( C1-C12) alkyl, (C1-C12) -alkoxy- (C1-C12) -alkoxy, (C6-C12) -aryloxy, (C7-C16) -aralkyloxy, (C1-C8) hydroxyalkyl, -O- [CH2 ] x-CfH (2f + 1-g) -Fg, -OCF2Cl, -OCF2-CHFCl, (C1-C12) -alkylcarbonyl, (C3-C8) -cycloalkylcarbonylp, (C6-C12) -arylcarbonyl, (C7-C16 ) -aralkylcarbonyl, cinnamoyl, (C2-C12) -alkenylcarbonyl, (C2-C12) -alkynylcarbonyl, (C1-C12) -alkoxycarbonyl, (C1-C12) -alkoxy- (C1-C12
