您的位置: 首页 > 农业专利 > 详情页

Carboxamide compounds and their use as calpain IV inhibitors
专利权人:
ABBOTT GMBH & CO. KG;ABBVIE INC.
发明人:
KLING, ANDREAS,JANTOS, KATJA,MACK, HELMUT,MÖLLER, ACHIM,HORNBERGER, WILFRIED,BACKFISCH, GISELA,LAO, YANBIN,NIJSEN, MARJOLEEN
申请号:
ES10798323
公开号:
ES2477583T3
申请日:
2010.12.21
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A carboxamide compound of the formula I ** Formula ** in which R1 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, wherein the last 3 mentioned radicals may be partially or totally halogenated and / or have 1 , 2 or 3 substituents R1a, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C4 alkyl, where a CH2 group in the cycloalkyl moiety of the last two mentioned radicals may be replaced by O, NH, or S, or two atoms Adjacent C may form a double bond, where the cycloalkyl moiety may also have 1, 2, 3 or 4 radicals R1b, aryl, heteroaryl, aryl-C1-C6 alkyl, aryl-C2-C6 alkenyl, C1-C4 heteroaryl-alkyl or C2-C6 heteroaryl-alkenyl, where aryl and heteroaryl in the last 6 radicals mentioned may not be substituted or have 1, 2, 3 or 4 identical or different R1c radicals; where R1a is independently selected from each other from OH, SH, COOH, CN, OCH2COOH, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C7 cycloalkyloxy, C1-C6 alkylthio, C1-C6 haloalkyl, COORa1, CONRa2Ra3, SO2NRa2Ra3 , - NRa2-SO2-Ra4, NRa2-CO-Ra5, SO2-Ra4 and NRa6Ra7, R1b is independently selected from each other from OH, SH, COOH, CN, OCH2COOH, halogen, phenyl which optionally has 1, 2 or 3 R1d substituents, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, where the alkyl moieties in the last 3 substituents mentioned may be partially or totally halogenated and / or have 1, 2 or 3 substituents R1a, COORb1, CONRb2Rb3, SO2NRb2Rb3, NRb2-SO2-Rb4, NRb2-CO-Rb5, SO2-Rb4 and NRb6Rb7, in addition two R1b radicals can together form a C1-C4 alkylene group, or 2 R1b radicals attached to adjacent C-cycloalkyl atoms can form together with the carbon atoms to which a benzene ring is also attached, R1c is independently selected from each other from OH, SH, halogen, NO2, NH2, CN, COOH, OCH2COOH, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkylthio, where the alkyl moieties in the last 4 substituents mentioned may be partial or totally halogenated and / or have 1, 2 or 3 substituents R1a, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C4 alkyl, C3-C7 c
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充