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carboxamide compounds and their use as calpain inhibitors
专利权人:
ABBVIE DEUTSCHLAND GMBH & CO KG;ABBVIE INC.
发明人:
KLING, ANDREAS,JANTOS, KATJA,MACK, HELMUT,MÖLLER, ACHIM,HORNBERGER, WILFRIED,BACKFISCH, GISELA,LAO, YANBIN,NIJSEN, MARJOLEEN
申请号:
ES10795007
公开号:
ES2525149T3
申请日:
2010.12.21
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A carboxamide compound of the formula I ** formula ** where R1 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, where the last 3 mentioned radicals may be partially or completely halogenated and / or have 1, 2 or 3 substituents R1a, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C4 alkyl, where a CH2 group in the cycloalkyl moiety of the last two radicals mentioned may be replaced by O, NH or S, or two adjacent C atoms they can form a double bond, where the cycloalkyl moiety can also have 1, 2, 3 or 4 radicals R1b, aryl, heteroaryl, aryl-C1-C6 alkyl, aryl-C2-C6 alkenyl, heteroaryl-C1-C4 alkyl or heteroaryl C2-C6 alkenyl, where aryl and heteroaryl in the last 6 radicals mentioned may be unsubstituted or carry 1, 2, 3 or 4 identical or different R1c radicals; where R1a is independently selected from OH, SH, COOH, CN, OCH2COOH, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C7 cycloalkyloxy, C1-C6 alkylthio, C1-C6 haloalkyl, COORa1, CONRa2Ra3, SO2NRa2Ra3, -NRa2-SO2- Ra4, NRa2-CO-Ra5, SO2-Ra4 and NRa6Ra7, R1b is independently selected from OH, SH, COOH, CN, OCH2COOH, halogen, phenyl which optionally has 1, 2 or 3 R1d substituents, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, where the alkyl moieties in the last 3 substituents mentioned may be partially or completely halogenated and / or have 1, 2 or 3 substituents R1a, COORb1, CONRb2Rb3, SO2NRb2Rb3, NRb2 -SO2-Rb4, NRb2-CO-Rb5, SO2-Rb4 and NRb6Rb7, in addition two radicals R1b radicals can together form a C1-C4 alkylene group, or 2 radicals R1b linked to adjacent C atoms of cycloalkyl can form together with the atoms of carbon to which a benzene ring is also attached, R1c is independently selected from each other from OH, SH, hal geno, NO2, NH2, CN, COOH, OCH2COOH, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkylthio, where the alkyl moieties in the last 4 substituents mentioned may be partial or completely halogenated and / or have 1, 2 or 3 substituents R1a, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C4 alkyl, C3-C7 cycloalkyloxy
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