BURY, MICHAEL JONATHAN,CASILLAS, LINDA N.,CHARNLEY, ADAM KENNETH,DEMARTINO, MICHAEL P.,DONG, XIAOYANG,HAILE, PAMELA A.,HARRIS, PHILIP ANTHONY,LAKDAWALA SHAH, AMI,KING, BRYAN W.,MARQUIS, ROBERT W.,MEHL
申请号：
ES11778419
公开号：
ES2552977T3
申请日:
2011.05.06
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound according to Formula (I) ** Formula ** in which: R1 is H, -SO2 (C1-C4 alkyl), -CO (C1-C4 alkyl), (C1-C4 alkyl) or phenyl ( C1-C4 alkyl) -； R2 is -SRa, -SORa, -SO2Ra, -SO2NH2, -SO2NRbRc or -CONRbRc, in which Ra is (C1-C6) alkyl, halo (C1-C4) alkyl, (C2-C6) alkenyl, cycloalkyl ( C3-C7), 4-7 membered heterocycloalkyl, aryl or heteroaryl, wherein: said (C1-C6) alkyl is optionally substituted with one or two groups each independently selected from cyano, hydroxyl, (C1-C6) alkoxy , (C1-C6) alkoxy (C2-C6) alkoxy, -CO2H, -CO2 (C1-C4) alkyl, - SO2 (C1-C4 alkyl), -CONH2, -CONH (C1-C4 alkyl), -CON ( C1-C4 alkyl) (C1-C4 alkyl), -SO2NH2, -SO2NH (C1-C4 alkyl), -SO2N (C1-C4 alkyl) (C1-C4 alkyl), amino, (C1-C4 alkyl) amino-, (C1-C4 alkyl) (C1-C4 alkyl) amino-, C3-C7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 9-10 member heteroaryl, 4-7 member heterocycloalkyl and (phenyl) (C1- alkyl C4) amino-, wherein said C3-C7 cycloalkyl, phenyl, (phenyl) (C1-C4 alkyl) amino-, 5-6 membered heteroaryl, 9-10 membered heteroaryl or 4-7 membered heterocycloalkyl is optionally their substituted with 1-3 groups each independently selected from halogen, -CF3, (C1-C4) alkyl, hydroxy (C1-C4) alkyl and (C1-C4) alkoxy, said cycloalkyl (C3-C7) or heterocycloalkyl of 4 -7 members is optionally substituted with 1-3 groups each independently selected from halogen, -CF3, hydroxyl, amino, (C1-C4) alkyl, phenyl-C1-C4 alkyl-, (C1-C4) alkoxycarbonyl- , hydroxy (C1-C4) alkyl -, oxo and (C1-C4) alkoxy, and said aryl or heteroaryl is optionally substituted with 1-3 groups each independently selected from halogen, -CF3, hydroxyl, amino, (C1 -C4), phenyl-(C1-C4) alkyl -, hydroxy-(C1-C4) alkyl - and (C1-C4) alkoxy； Rb is (C1-C6) alkyl, (C3-C7) cycloalkyl, 4-7 membered heterocycloalkyl, aryl or heteroaryl, wherein: said (C1-C6) alkyl is optionally substituted with one or two groups each independently selected between cyano, hydroxyl, (C1-C6) alkoxy, (C1-C6) alkoxy (C2-C6) alkoxy, -CO2H, -CO2 (C1-C4) alkyl, -
