GlaxoSmithKline Intellectual Property Development Limited
发明人:
NEIPP, Christopher E.,PALOVICH, Michael R.
申请号：
ES12744272
公开号：
ES2583091T3
申请日:
2012.02.09
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound according to Formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 are each independently selected from the group consisting of hydrogen, (C1-C8) alkyl, alkenyl (C2-C8) ), alkynyl (C2-C8), cycloalkyl (C3-C8), cycloalkenyl (C5-C8), bicycloalkyl (C6-C10), heterocycloalkyl, cycloalkyl (C3-C8) alkyl (C1-C6), cycloalkenyl (C5-C8) ) (C1-C6) alkyl, heterocycloalkylalkyl (C1-C6), aryl, heteroaryl, arylalkyl (C1-C6), and heteroarylalkyl (C1-C6) alkyl； wherein any (C1-C8) alkyl, (C2-C8) alkenyl, or (C2-C8) alkynyl optionally is substituted one to three times, independently, by -CF3, cyano, -CO2alkyl (C1-C4), -COHNalkyl (C1- C4), -CONalkyl (C1-C4) alkyl (C1-C4), -SO2alkyl (C1-C4), -SO2NHalkyl (C1-C4), -SO2Nalkyl (C1-C4) alkyl (C1-C4) ), amino, (C1-C4) alkylamino, ((C1-C4) alkyl) ((C1-C4) alkyl) amino, hydroxyl, or (C1-C4) alkoxy； and wherein any cycloalkyl, cycloalkenyl, bicycloalkyl, or heterocycloalkyl group is optionally substituted one to three times, independently, by (C1-C4) alkyl, halo (C1-C4) alkyl, cyano, -CO2alkyl (C1-C4) alkyl, -COHN (C1-C4) alkyl, -CONalkyl (C1-C4) alkyl (C1-C4), - SO2alkyl (C1-C4), -SO2NHalkyl (C1-C4), -SO2Nalkyl (C1-C4) alkyl (C1-C4) ), amino, (C1-C4) alkylamino, ((C1-C4) alkyl) ((C1-C4) alkyl) amino, hydroxyl, (C1-C4) alkoxy, aryl, or (C1-C4) alkylalkyl, in the that the aryl moiety of said aryl or aryl (C1-C4) alkyl is optionally substituted one to three times, independently, by halogen, -CF3, (C1-C4) alkyl, hydroxyl, or (C1-C4) alkoxy； and wherein any aryl or heteroaryl group is optionally substituted one to three times, independently, by halogen, (C1-C6) alkyl, cycloalkyl (C3-C6), cycloalkenyl (C5-C6), haloalkyl (C1-C6), cyano, -CO2 (C1-C4) alkyl, -CONHalkyl (C1-C4), -CONalkyl (C1-C4) alkyl (C1-C4), - SO2alkyl (C1-C4), -SO2NHalkyl (C1-C4), -SO2Nalkyl (C1-C4) (C1-C4) alkyl, amino, non-C1-C4 alkylamine, (C1-C4) alkyl ((C1-C4) alkyl) amino, hydroxyl, (C1-C4) alkoxy, alkylthio (C1-C4) -, aryl, heteroaryl, arylalk
