GOBBI LUCA,RODRIGUEZ SARMIENTO ROSA MARIA,WICHMANN JUERGEN
申请号：
ARP110102108
公开号：
AR082004A1
申请日:
2011.06.17
申请国别(地区):
AR
年份:
2012
代理人:
摘要：
This table deals with dual modulators for 5-htma receivers and D3 receivers. This note also deals with the extraction of compounds from formula (1),A pharmaceutical compounds containing these substances and their use as drugs 1: a compound of formula (1), wherein X is or s； and es-c (o) - O-S (o) 2；A is a single bond or a double bond, provided that if X is S, then A is a double bond； R1 is hydrogen, C1-7 alkyl, C1-7 haloalkyl, C2-7 alkenyl, C2-7 alkynyl, cycloalkyl, heterocycloalkyl, aryl, aryl fused with a heterocycloalkyl, heteroaryl, -N (R6) 2, said C1-7 alkyl , C1-7 haloalkyl, C2-7 alkenyl, C2-7 alkynyl are optionally substituted one to three times by substituents independently chosen from the group consisting of cyano, cycloalkyl, heterocycloalkyl, aryl, aryl fused with heterocycloalkyl, heteroaryl, - C (O) N (R6) 2, -N (R6) 2, -NH (CO) -C 1-7 alkyl, hydroxy, C 1-7 alkoxy, halo C 1-7 alkoxy,oxo and -S (O) 2R7 and said cycloalkyl, heterocycloalkyl, aryl, aryl fused with a heterocycloalkyl and heteroaryl are optionally substituted one to three times by independent R4； R 2, R 3 are independently hydrogen, halogen, C 1-7 alkyl, C 1-7 haloalkyl, hydroxy, C 1-7 alkoxy or C 1-7 haloalkoxy； R4 is halogen, cyano, C1-7 alkyl, C1-7 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, aryl fused with a heterocycloalkyl, heteroaryl, -C (O) N (R6) 2, -N (R6) 2, -NH (CO) -C 1-7 alkyl, hydroxy, C 1-7 alkoxy, halo C 1-7 alkoxy, oxo, -S (O) 2R7 or C 1-7 alkyl substituted one to three times by substituents independently chosen from the group consisting of cyano,Hydrogen Xi, alcox c1-7 and halocycloxy c1-7, these cyclododecanes, isocyclododecanes, arilo and isomers can be replaced by one to three independent R5； R5 is halogen, cyanogen, c1-7 tar, c1-7 halo-7, hydroxyhydrogen, c1-7 or oxo； R6 is hydrogen or c1-7 tar； R7 is hydrogen, C1-7 or arilo, optionally one to three times replaced with an independent R5； and pharmaceutically acceptable salts and esters.La presente se refiere a modul
