BAKER-GLENN, Charles,BURDICK, Daniel Jon,CHAMBERS, Mark,CHEN, Huifen,ESTRADA, Anthony,SWEENEY, Zachary Kevin,CHAN, Bryan K.
申请号：
ES11782588
公开号：
ES2653967T3
申请日:
2011.11.09
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, in which: X is: -NRa-； or -O- where Ra is hydrogen； R1 is: C1-6 alkyl； R2 is: halo； cyano； or halo- C1-6 alkyl； R3 is: hydrogen； C1-6 alkyl； halo C1-6 alkyl； C2-6 alkenyl； C2-6 alkynyl； hydroxyC 1-6 alkyl； C1-6 alkoxy-C1-6 alkyl； cyano-C1-6 alkyl； C1-6 alkylsulfonyl； C1-6 alkylsulfonyl-C1-6 alkyl； amino C1-6 alkyl； C3-6 cycloalkyl optionally substituted one or more times with Ra15； C3-6 cycloalkyl-C1-6 alkyl wherein the C3-6 cycloalkyl portion is optionally substituted one or more times with R6； C3-6 cycloalkyl sulfonyl, wherein the C3-6 cycloalkyl portion is optionally substituted one or more times with R6； heterocyclyl optionally substituted one or more times with R7； heterocyclyl-C 1-6 alkyl, wherein the heterocyclyl portion is optionally substituted one or more times with R 7； aryl optionally substituted one or more times with R8； aryl-C 1-6 alkyl, wherein the aryl portion is optionally substituted one or more times with R 8； heteroaryl optionally substituted one or more times with R8； heteroaryl-C 1-6 alkyl, wherein the heteroaryl portion is optionally substituted one or more times with R 8； or -Y-C (O) -Rd； Y is C2-6 alkylene or a bond； Rd is C1-6 alkyl, C1-6 alkoxy, amino, C1-6-alkyl, di-C1-6-alkyl, halo-C1-6-alkyl, di-halo-C1-6-alkyl, halo-C 1-6 alkyl, hydroxy-C 1-6 alkyl, hydroxy, C 1-6 alkoxy-C 1-6 alkyl, cyano-C 1-6 alkyl, C 1-6 alkylsulfonyl-C 1-6 alkyl, aminoC 1-6 alkyl, C3-6 cycloalkyl optionally substituted one or more times with R6, C3-6 cycloalkyl-C1-6 alkyl, wherein the C3-6 cycloalkyl portion is optionally substituted one or more times with R6, heterocyclyl optionally substituted one or more times with R7, or heterocyclyl-C1-6 alkyl, wherein the heterocyclyl portion is optionally substituted one or more times with R7； R4 is: hydrogen； C1-6 alkyl； halo； cyano； halo C1-6 alkyl； C2-6 alkenyl； C2-6 alkynyl； C1-6 alkoxy； C1-6 alkoxy-C1-6 alkyl； hydroxyC 1-4 alkyl；
