KOBAYASHI, TETSUYA,KOLTUN, DMITRY,NOTTE, GREGORY,PARKHILL, ERIC,ZABLOCKI, JEFF
申请号：
ES11732540
公开号：
ES2529119T3
申请日:
2011.06.30
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of Formula II: ** Formula ** in which: X is -O-CF3 or -CF3； each R 'and R "is hydrogen； R2 is hydrogen, C1-15 alkyl, C1-8 alkoxy, -C (O) -O-R26, -C (O) -N (R26) (R28), -N ( R20) -S (O) 2-R20, cycloalkyl, aryl, heteroaryl or heterocyclyl, wherein said C1-15 alkyl is optionally substituted with one, two or three substituents independently selected from hydroxyl, C1-8 alkoxy, halo, - NO2, -O-CF3, -O-CHF2, C2-4 alkenyl, C2-4 alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, -N (R20) (R22), -C (O) R20, -C (O ) -O-R20, -C (O) -N (R20) (R22), -CN, and -O-R20, and wherein said C1-8 alkoxy, C2-4 alkenyl, C2-4 alkynyl, aryl, heterocyclyl , heteroaryl or cycloalkyl are optionally substituted with one, two or three substituents independently selected from hydroxyl, halo, -NO2, -O-CF3, C1-6 alkyl, C1-4 alkoxy, aralkyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, - N (R20) (R22), -C (O) R20, -C (O) -O- R20, -C (O) -N (R20) (R22), -CN and -O-R20, and where said C1-6 alkyl, C1-4 alkoxy, aralkyl, aryl, heterocyclyl, hete roaryl or cycloalkyl are optionally further substituted with one, two or three substituents independently selected from deuterium, hydroxyl, halo, -NO2, -O-CF3, -CF3, -O-CHF2, -N (R20) (R22), -C (O) R20, -C (O) -O-R20, -C (O) -N (R20) (R22), -CN and -O-R20； R3 is selected from the group consisting of hydrogen, hydroxyl, halo, C1-4 alkyl, C1-3 alkoxy, -R25-N (R20) (R22), -R25-O-R20, -R25-C (O) -O-R20, -R25-C (O) -N (R20) (R22), -R25-C (O) -ON (R20) (R22), -R25-N (R20) -C (O) - R22 and -R25-OC (O) -N (R20) (R22), and wherein said C1-4 alkyl is optionally substituted with one, two or three substituents independently selected from hydroxyl and halo； R4 is selected from the group consisting of hydrogen, optionally substituted alkyl, aryl, -CF3, -halo and -O-R24, and wherein said aryl is optionally further substituted with one, two or three substituents independently selected from hydroxyl, halo , -NO2, -O-CF3, C1-6 alkyl, C1-4 alkoxy, aralkyl, aryl, heteroc
