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Arylimidazolones and substituted aryltriazolones as vasopressin receptor inhibitors
专利权人:
BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
MEIER, HEINRICH,BENDER, ECKHARD,BRUEGGEMEIER, ULF,FLAMME, INGO,KARTHAUS, DAGMAR,KOLKHOF, PETER,MEIBOM, DANIEL,SCHNEIDER, DIRK,VOEHRINGER, VERENA,FUERSTNER, CHANTAL,KELDENICH, JOERG,LANG, DIETER,POOK,
申请号:
ES07725514
公开号:
ES2385606T3
申请日:
2007.05.23
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compound of formula (I) ** Formula ** in which A represents N or C-R4, in which R4 means hydrogen or (C1-C4) alkyl, R1 represents (C1-C6) alkyl, (C2-C6) alkenyl or (C2-C6) alkynyl, which may be substituted respectively one to three times, in the same or different manner, with moieties selected from the halogen, cyano, oxo, trifluoromethyl, cycloalkyl (C3-C7), phenyl, -OR10 series, - NR11R12, -C (>; = O) -OR13 and -C (>; = O) -NR14R15, in which (i) the cycloalkyl (C3-C7) can be substituted up to twice equally or differently with (C1) alkyl -C4), oxo, hydroxyl, (C1-C4) alkoxy and / or amino, (ii) the phenyl may be substituted up to three times, in the same or different manner, with moieties selected from halogen, cyano, nitro, alkyl ( C1-C4), trifluoromethyl, hydroxy, hydroxymethyl, (C1-C4) alkoxy, trifluoromethoxy, (C1-C4) alkoxy, hydroxycarbonyl, (C1-C4) alkoxycarbonyl, aminocarbonyl, mono (C1-C4) -aminocarbonyl and dialkyl (C1-C4) -aminocarbonyl, (iii) R10, R11, R12, R13, R14 and R15 independently mean each other in each individual occurrence hydrogen, (C1-C6) alkyl or cycloalkyl (C3-C7), in which the (C1-C6) alkyl may in turn be substituted up to two times, in the same or different way, with amino, hydroxyl, (C1-C4) alkoxy, hydroxycarbonyl and / or (C1-C4) alkoxycarbonyl and cycloalkyl (C3-C7) can be substituted in turn up to twice, so same or different, with (C1-C4) alkyl, oxo, hydroxyl, (C1-C4) alkoxy and / or amino, and / or (iv) R11 and R12, as well as R14 and R15, respectively form in pairs, together with the nitrogen atom to which they are attached, a 4- to 7-membered heterocycle that may contain an additional heteroatom of the N, O and S series and be substituted up to twice, in the same or different manner, with (C1-C4) alkyl, oxo , hydroxyl, (C1-C4) alkoxy and / or amino, oR1 represents (C3-C7) cycloalkyl which may be substituted up to twice, in the same or different manner, with (C1-C4) alkyl, (C1-C4) alkoxy hydroxyl or, amino and / or oxo, R2 repres
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