THEDE, Kai,FLAMME, Ingo,OEHME, Felix,ERGÜDEN, Jens-Kerim,STOLL, Friederike,WILD, Hanno,KOLKHOF, Peter,BECK, Hartmut,JESKE, Mario
申请号：
ES07819021
公开号：
ES2595501T3
申请日:
2007.10.16
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound of formula (I) ** Formula ** in which A represents CH, R 1 represents a substituent selected from the series of cycloalkyl (C3-C6), 4-6 membered heterocycloalkyl, phenyl, 5- or 6-membered heteroaryl, -OC (>； = O) -NR9R10, -NR11-C (>； = O) -R12, -NR13-C (>； = O) -OR14, -NR15- C (>； = O) -NR16R17, -NR18-SO2 -R19 and -NR25R26, in which (i) C3-C6 cycloalkyl, 4-6 membered heterocycloalkyl, 5 or 6 membered phenyl and heteroaryl on the other hand in each case may be substituted one to three times, of in the same or different manner, with moieties selected from the series of (C1-C6) alkyl, halogen, cyano, oxo, hydroxyl, amino, hydroxycarbonyl, aminocarbonyl, -C (>； = O) -NR6R7, -OC (>； = O) -NR9R10, -NR11-C (>； = O) -R12, -NR13-C (>； = O) -OR14, -NR15-C (>； = O) - NR16R17, -NR18-SO2-R19, -OR23 and - NR25R26, the last mentioned alkyl moiety may be substituted on its part up to three times, in the same or different manner, with halogen, cyano, hydroxyl, trifluoromethoxy, (C1-C4) alkoxy, am ino, mono (C1-C4) -amino, di-(C1-C4) alkyl-amino, hydroxycarbonyl, (C1-C4) alkoxycarbonyl, (C3-C6) cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl and / or 5- or 6-membered heteroaryl, (ii) R6, R9, R12, R14, R16, R19, R23 and R25 independently of each other in each individual occurrence represent a moiety selected from the (C1-C6) alkyl, cycloalkyl ( C3-C6) and 4 to 6-membered heterocycloalkyl, and cycloalkyl (C3-C6) and 4 to 6-membered heterocycloalkyl may be substituted for their part in each case up to three times, equally or differently, with halogen, cyano, alkyl (C1-C4), trifluoromethyl, hydroxy, (C1-C4) alkoxy, trifluoromethoxy, oxo, amino, mono (C1-C4) alkyl-amino, di-(C1-C4) alkyl-amino, hydroxycarbonyl and / or alkoxy (C1-C4) -carbonyl and may be substituted (C1-C6) alkyl one to three times, in the same or different manner, with halogen, cyano, hydroxyl, trifluoromethoxy, alkoxy (C1-C4), amino, mono-alkyl (C1-C4) -amino, di-al C 1 -C 4 -amino, hydr
