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3-Acetylamino-1- (phenyl-heteroaryl-aminocarbonyl or phenyl-heteroaryl-carbonylamino) benzene derivatives for the treatment of hyperproliferative disorders
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
THEDE, Kai,BENDER, Eckhard,SCOTT, William J.,RICHTER, Anja,ZORN, Ludwig,LIU, Ningshu,MÖNNING, Ursula,SIEGEL, Franziska,GOLZ, Stefan,HÄGEBARTH, Andrea,LIENAU, Philip,PUEHLER, Florian,BASTING, Daniel,SC
申请号:
ES14712631
公开号:
ES2641478T3
申请日:
2014.03.17
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of general formula (I): ** Formula ** in which: LA represents a methylene or ethylene group, said methylene or ethylene group being optionally substituted, one or more times, identically or differently, with a substituent selected among: hydroxy, cyano, C1-C3 alkyl, C1-C3 alkoxy, halo C1-C3 alkyl, hydroxy C1-C3 alkyl, halo C1-C3 alkoxy, C3-C7 cycloalkyl, 3 to 10 membered heterocycloalkyl; or, when two substituents are present in the same carbon atom, the two substituents, together with the carbon atom to which they are attached, can form a C3-C6 cycloalkyl or 3 to 6 membered heterocycloalkyl ring; wherein said ring is optionally substituted one or more times, identically or differently, with a substituent selected from: halo, hydroxy, cyano, C1-C3 alkyl, C1-C3 alkoxy; LB represents -N (H) -C (>; = O) - or -C (>; = O) -N (H) -; R1 represents a group selected from: 5-8 membered heterocycloalkyl, 4-10 membered heterocycloalkenyl, aryl, heteroaryl and -N (R7) - (C1-C6 alkyl); wherein said 5 to 8 membered heterocycloalkyl, 4 to 10 membered heterocycloalkenyl, aryl, heteroaryl and group -N (R7) - (C1-C6 alkyl) is optionally substituted, one or more times, identically or differently, with a substituent selected from: halo, hydroxy, cyano, C1-C3 alkyl, C1-C3 alkoxy, halo-C1-C3 alkyl, hydroxy-C1-C3 alkyl, halo-C1-C3 alkoxy, C3-C7 cycloalkyl; R2 represents a group selected from: ** Formula ** in which "*" indicates the point of attachment to R3 and "**" indicates the point of attachment to LB; wherein said group is optionally substituted, one or more times, identically or differently, with a C1-C3 alkyl group; R3 represents a phenyl group, said phenyl group being optionally substituted, one or more times, identically or differently, with a substituent selected from: ** Formula ** halo, hydroxy, -N (R9) (R10), -N (H) C (>; = O) R9, cyano, nitro, C1-C3 alkyl, C1-C3 alkoxy, halo-C1-C3 alkyl, hydroxy-C1-C3 alkyl, amino-C1-C3 alkyl, halo-C1 alkoxy -C3; R4 represen
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