GRIFFIOEN, Gerard,DE TAEYE, Bart,PRINCEN, Katrien,DE WITTE, Koen,BLANCHE, Emilie,RATNI, Hasane,ROGERS-EVANS, Mark
申请号：
ES15710486
公开号：
ES2666173T3
申请日:
2015.03.17
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, ** Formula ** wherein, n is an integer selected from 0, 1, 2 or 3； R1 is selected from the group consisting of C1-6 alkyl, halo, C1-6 haloalkyl, and C1-6 haloalkyloxy； R3 is selected from the group consisting of C6-12 aryl, hydrogen, C1-6 alkyl, C3-12 cycloalkyl, heterocyclyl, heteroaryl, C6-12 aryl-C1-6 alkyl, C6-12 aryl-C1-6 alkyl-aryl C6-12, halo, hydroxyl, -OR18, -SR19, C1-6 haloalkyl, C1-6 haloalkyloxy, amino, -NR20R21, and cyano； wherein said C6-12 aryl, C1-6 alkyl, C3-12 cycloalkyl, heterocyclyl, heteroaryl, C6-12 aryl-C1-6 alkyl, or C6-12 aryl-C1-6 alkyl-C6-12 aryl may be unsubstituted or substituted with one or more Z1； L1 is selected from the group consisting of -SO2-, -CO -, ** Formula ** and； in which * represents where L1 is attached to L2； and ** represents where L1 is attached to the azetidine ring； and in which, A1 is S or O； q is an integer selected from 0, 1, 2 or 3； L6 is -CO- or -SO2-, each R2 is independently selected from the group consisting of C1-6 haloalkyloxy, -OR18, halo, hydrogen, C1-6 alkyl, C1-6 haloalkyl, C3-12 cycloalkyl, C6 aryl- 12, C6-12 aryl-C1-6 alkyl, heterocyclyl, heteroaryl, hydroxyl, SR19, cyano, amino, -NR20R21, -CO2R22, -C (O) NR20R21, -C (O) R22, -S (O) R22 , -S (O) 2R22, -SO2NR20R21, nitro, - NR23C (O) R22, -R24-C (O) NR20R21, -NR23S (O) 2R22, and -NR23C (O) NR20R21； wherein two R2 together with the atom to which they are attached can form a saturated, unsaturated ring of 5, 6, or 7 members； and wherein at least one carbon atom or heteroatom of said ring, C6-12 aryl, C3-8 cycloalkyl, heterocyclyl, heteroaryl can be oxidized to form at least one C>； = O, C>； = S, N>； = O , N>； = S, S>； = O or S (O) 2； R4 is selected from the group consisting of C6-12 aryl, hydrogen, C1-6 alkyl, C3-12 cycloalkyl, heterocyclyl, heteroaryl, C6-12 aryl-C1-6 alkyl, C6-12 aryl-C1-6 alkyl-aryl C6-12, halo, hydroxyl, -OR18, -SR19, C1-6 haloalkyl, C1-6
