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Cyanoguanidines and their use as antiviral agents
专利权人:
AbbVie Inc.
发明人:
GOMTSIAN, Artour,DEKHTYAR, Tatyana,FRANK, Kristine E.,FRIEDMAN, Michael M.,JOSEPHSOHN, Nathan,MOLLA, M-Akhteruzz,VASUDEVAN, Anil,NG, Teresa,CHAFEEV, Mikhail
申请号:
ES13735554
公开号:
ES2673221T3
申请日:
2013.06.28
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound for use in preventing and / or treating RSV infection, or in preventing and / or inhibiting replication of a ribonucleic acid virus (RNA), the compound having the formula (I), formula (II), formula (III ) or formula (IV), or a pharmaceutically acceptable salt thereof, ** Formula ** in which: Ar1 is phenyl or monocyclic heteroaryl having a structure corresponding to a formula selected from the group consisting of: ** Formula ** in which R1A is selected from the group consisting of hydrogen; Not me; hydroxyl; cyano; halogen; C1-C6 alkyl; C1-C6 alkenyl; C1-C6 alkynyl; C1-C6 alkoxy; haloalkyl; haloalkoxy; oxoalkyl; alkylamino; dialkylamino; alkoxyalkyl; aminoalkyl; N-alkylaminoalkyl; N, N-dialkylaminoalkyl; -L1-C (O) -OR1 'or -L1- S (O) 2R1', in which L1 is a bond or alkylene and R1 'is hydrogen, C1-C6 alkyl or hydroxyalkyl; -L2-O-C (O) - R2 ', wherein L2 is a bond or alkylene and R2' is C1-C6 alkyl or hydroxyalkyl; -L3-C (O) -NR3'R4 ', wherein L3 is a bond or alkylene and R3' and R4 'are each independently selected from the group consisting of hydrogen, alkyl and hydroxyalkyl; -L4-NR5-C (O) -R6 ', in which L4 is a bond or alkylene, R5' is hydrogen or alkyl and R6 'is alkyl or hydroxyalkyl; sulfamoyl; N- (alkyl) sulfamoyl; N, N- (dialkyl) sulfamoyl; sulfonamide; alkylthio; and thioalkyl; R1B, R1C, R1D and R1E are each independently selected from the group consisting of hydrogen, cyano, halogen, C1-C6 alkyl, alkoxy, amino, alkylamino, dialkylamino, cycloalkyl, heterocyclyl, haloalkoxy and haloalkyl; or R1B and R1C, or R1C and R1D, or R1D and R1E taken together are -O-CH2-O-; X1A, X1B, X1C, X1D and X1E are CR1AX, CR1BX, CR1CX, CR1DX and CR1EX, respectively, or N; in which 1, 2 or 3 of X1A, X1B, X1C, X1D and X1E are N; in which R1AX is selected from the group consisting of hydrogen; Not me; hydroxyl; cyano; halogen; C1-C6 alkyl; C1-C6 alkenyl; C1-C6 alkynyl; haloalkyl; haloalkoxy; oxoalkyl; alkoxy; alkylamino; dialkylamino; alkoxyalkyl; aminoalkyl; N-alkylaminoa
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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