The invention relates to compounds of general formula (I):, wherein X1 is hydrogen or halogen or C1-C6-alkyl X2 is hydrogen or halogen, C1-C6-alkyl, C1-C6-fluoroalkyl or S(O)2-C1-C6-alkyl X3 and X4, independently of one another, are hydrogen or halogen, C1-C6-alkyl, C1-C6-fluoroalkyl, C1-C6-alkoxy, NR1R2 or C1-C6-thioalkyl wherein Z1, Z2, Z3, and Z4 represent, independently of one another, a nitrogen atom or a C(R6) group, at least one of Z1, Z2, Z3, and Z4 corresponds to a nitrogen atom and at least one of Z1, Z2, Z3, and Z4 corresponds to a C(R6) group n is equal to 1 Y represents phenyl or pyridinyl optionally substituted by or several groups selected from halogen, C1-C6-alkyl or NR1R2 Z represents a cyclic amine selected from azetidine, pyrrolidine, piperidine, morpholine, azabicylo[3.1.0]hexane and azabicylo[3.2.0]heptane it being possible for the nitrogen atom of the cyclic amine Z to be in N-oxide form the carbon atoms of the cyclic amine Z being optionally substituted with a group R12 R1 and R2 are independently of one another, hydrogen or C1-C6-alkyl or R1 and R2 taken together with the nitrogen atom to which they are attached pyrrolidinyl R3 is hydrogen R5 is C1-C6-alkyl R6 is hydrogen, halogen, C1-C6-alkyl C1-C6-fluoroalkyl or C1-C6-alkoxy, R12 is NR1R2, NR3COOR5 or hydroxy in the base or acid addition salt state, and in the hydrate or solvate state. The invention also relates to a preparation method of a compound of formula (I), amine of general formula (V) characterized in invention claims and to a pharmaceutical composition comprising the compound of formula (I).Изобретение относится к соединениям общей формулы (I), в которой Х1 обозначает атом водорода или галогена либо C1-C6-алкил Х2 обозначает атом водорода или галогена, C1-C6-алкил, C1-C6-фторалкил или -S(О)2-C1-C6-алкил Х3 и Х4 обозначают независимо друг от друга атом водорода или галогена, C1-C6-алкил, C1-C6-фторалкил, C1-C6-алкоксил, NR1R2 или C1-C6-тиоалкил Z1, Z2, Z3 и Z4 обозначают независимо
