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Novel compounds as inhibitors of histone deacetylase 6 and pharmaceutical compositions comprising the same
专利权人:
Chong Kun Dang Pharmaceutical Corp.
发明人:
SONG, Hyeseung,LEE, Changgon,KWAK, Dalyong,LEE, Jaeyoung,BAE, Suyeal,KIM, Yuntae,BAE, Daekwon,HA, Nina,BAE, Miseon,KIM, Jihyun,SONG HYESEUNG,LEE CHANGGON,KWAK DALYONG,LEE JAEYOUNG,BAE SUYEAL,KIM YUNTAE,BAE DAEKWON,HA NINA,BA
申请号:
ES15762410
公开号:
ES2694053T3
申请日:
2015.03.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound represented by the following formula I, a stereoisomer thereof or a pharmaceutically acceptable salt thereof: ** Formula ** wherein R1 is hydrogen or -CH3, R2 is hydrogen or -CH3, with the proviso that R2 is -CH3 when R1 is hydrogen, and R2 is hydrogen when R1 is -CH3 L is - (C4-C5 alkyl) -; - (C1-C3 alkyl) -L1-; -C (>; = O) -L1- or -S (>; = O) 2-L1-, where - (C4-C5 alkyl) - and - (C1-C3 alkyl) - can be unsubstituted or substituted with - CH3, L1 is -cycloalkyl (C3-C6) -; ** Formula ** A1 and A2 are each independently -N- or -CR3-, provided that both A1 and A2 cannot be - N-, R3 it is hydrogen; -F, -Cl, -Br, -I or -OH, and A3 is -NH- or -O-, Q is selected from the group consisting of -alkyl (C1-C6) -; -alkenyl (C2-C6) -; -C (>; = O) -; -C (>; = S) -; -S (>; = O) 2- or ** Formula ** where -alkyl (C1-C6) - and -alkenyl (C2-C6) - can be unsubstituted or substituted each with 1 to 3 groups -CH3 or halogen atoms, Q1 is hydrogen; -F, -Cl, -Br or -I, n is an integer of 0, 1 or 2, provided that n is 0 when Q is ** Formula ** n is 1 when Q is -C (>; = O) -; -C (>; = S) - or -S (>; = O) 2-, and n is 1 or 2 when Q is -alkyl (C1-C6) - or -alkenyl (C2-C6) -, and X can be selected from group consisting of -C1-C6 alkyl; -C3-C6 cycloalkyl; -C2-C6 alkenyl; - C3-C6 cycloalkenyl; - (C0-C2 alkyl) Ar; -OAr; - (C0-C2 alkyl) Het; naphthyl and the following groups: ** Formula ** in which R4 is H or -C1-C4 alkyl, -C0-C2 alkyl, -C2-C6 alkenyl and -C1-C6 alkyl may be unsubstituted or substituted with 1 to 2 -CH3 groups; 1 to 3 -F groups, or a combination thereof, Ar is a monocyclic aromatic C6 compound, which may be unsubstituted or substituted with one or more halogen atoms; -OH; -NH2; -C1-C6 alkyl; -C1-C6 alkyl; -C3-C6 cycloalkenyl; -NH (C1-C6 alkyl); -N (C1-C3 alkyl) 2; -CH2N (C1-C3 alkyl) 2; -S (>; = O) 2- (C1-C3 alkyl) or phenyl groups, wherein -C1-C3 alkyl; -C1-C6 alkyl and - C3-C6 cycloalkenyl can each be independently substituted with 1 to 5 -F or -CH3 gro
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