A compound of formula I-0: ** ** Formula or a pharmaceutically acceptable salt thereof, wherein: - ------- is a single bond or a double bond R1 is H, CH3, CF3, F , Cl, Br or -OCF3 R2 is H, C1-6 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl or C6-10 aryl wherein each C1-6 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl or C6-10 aryl is substituted with 0, 1, 2, 3, 4 or 5 substituents each independently selected from OH, amino, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and C1-6 haloalkoxy R3 is NR3aR3b, wherein R3a is H, C1-6 alkyl, C1-6 haloalkyl, cycloalkylalkyl, C3-7 cycloalkyl, C6-10 arylalkyl or aryl wherein each C1-6 alkyl, C1-6 haloalkyl, cycloalkylalkyl, C3-7 cycloalkyl, C6-10 arylalkyl or aryl, substituted with 0, 1, 2, 3, 4 or 5 substituents each independently selected from OH, amino, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and C1-6 haloalkoxy and R3b is H, C1-6 alkyl, C1-6 haloalkyl, cycloalkylalkyl, C3-7 cycloalkyl, C6-10 arylalkyl or aryl wherein each C1-6 alkyl, C1-6 haloalkyl, cycloalkylalkyl, cycloalkyl C3- 7, arylalkyl or C6-10aryl, is substituted with 0, 1, 2, 3, 4 or 5 substituents each independently selected from OH, amino, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and C1-6 haloalkoxy or R3a and R3b together with the N atom to which they are attached form a each independently selected from heterocycloalkyl group 4, 5, 6 or 7 members which is substituted with 0, 1, 2, 3, 4 or 5 substituents OH, amino, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl and R4 is H, C1-6 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl or C6-10 aryl wherein each C1-6 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl or C6-10 aryl is substituted with 0, 1, 2, 3, 4 or 5 substituents each independently selected OH, amino, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and C1- 6 haloalkoxy.Un compuesto de Fórmula de I-0: **Fórmula** o una sal farmacéuticamente aceptable del mismo, en donde: - ------- es un
