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Hepatitis C virus inhibitors
专利权人:
LLC;Theravance Biopharma R&D IP
发明人:
MCKINNELL, Robert Murray,LONG, Daniel D.
申请号:
ES13719696
公开号:
ES2599665T3
申请日:
2013.04.24
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I): ** Formula ** or of formula (II): ** Formula ** in which the discontinuous bond of formula (II) may be present or absent; W is selected from ** Formula ** and G is R1 is selected from C1-6 alkyl, C1-6 alkoxy, phenyl, C3-6 cycloalkyl, heterocycle and heteroaryl, wherein C1-6 alkyl is optionally substituted with -ORa , amino, -SRe, heterocycle or heteroaryl, C1-6 alkoxy is optionally substituted with -ORa and heterocycle is optionally substituted with -ORa, amino or -C (O) or C1-6 alkyl, or with one or two C1- alkyl 3; R2 is selected from hydrogen and C1-6 alkyl; R3 is selected from hydrogen, C-6 alkyl, -C (O) O C1-6 alkyl, -C (O) NRbRc, -C (O) C3-6 cycloalkyl and -S (O) 2 C1-3 alkyl; R4 is selected from C1-6 alkyl, C3-6 cycloalkyl and halo; R5 is selected from hydrogen, C1-6 alkyl, -ORd, halo, -S (O) C1-3 alkyl, -S (O) 2 C1-3 alkyl, NRbRc, -CN and - C (O) NRbRc; R6 is independently selected from hydrogen, C1-6 alkyl and halo; R7 is selected from halo, C1-3 alkyl and C1-3 alkoxy in which C1-3 alkyl and C1-3 alkoxy are optionally substituted with one, two, three, four or five halo; R8 is C1-3 alkyl, optionally substituted with -ORd; R9 is selected from C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, -NRfRg, heteroaryl, heterocycle and -CH2-heteroaryl; wherein: C1-6 alkyl is optionally substituted with one or two substituents independently selected from -ORh, -NRjRk, -NHC (O) C1-3 alkyl, -NHC (O) C3-6 cycloalkyl, and -NHC (O ) Or C1-3 alkyl; C1-6 alkoxy is optionally substituted with -ORh;Un compuesto de fórmula (I):**Fórmula** o de fórmula (II):**Fórmula** en las que el enlace discontinuo de la fórmula (II) puede estar presente o ausente; W se selecciona entre**Fórmula** y G es R1 se selecciona entre alquilo C1-6, alcoxi C1-6, fenilo, cicloalquilo C3-6, heterociclo y heteroarilo, en los que alquilo C1-6 está opcionalmente sustituido con -ORa, amino, -SRe, heterociclo o heteroarilo, alcoxi C1-6 está opcionalmente sustituido con -ORa y heterociclo es
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