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Compounds and compositions as protein kinase inhibitors
专利权人:
Array Biopharma Inc.
发明人:
Huang, Shenlin,Jin, Xianming,Liu, Zuosheng,Poon, Daniel,Tellew, John,Wan, Yongqin,Wang, Xing,Xie, Yongping
申请号:
ES14152945
公开号:
ES2610825T3
申请日:
2010.08.27
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of Formula I: ** Formula ** in which: Y is selected from N and CR6; R1 is -CH2CHMeNH (CO) OMe; R2, R3, R5 and R6 are independently selected from hydrogen, halo, cyano, C1-4 alkyl, halo substituted C1-4 alkyl, C1-4 alkoxy and halo substituted C1-4 alkoxy; with the proviso that when R5 is fluorine, R3 and R6 are not both hydrogen; R4 is selected from -R9 and -NR10R11; wherein R9 is selected from C1-6 alkyl, C3-8 cycloalkyl, C3-8 heterocycloalkyl, aryl and heteroaryl; wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl of R9 are optionally substituted with 1 to 3 radicals independently selected from halo, cyano, C1-4 alkyl, halo substituted C1-4 alkyl, C1-4 alkoxy and C1- alkoxy 4 halo-substituted; and R10 and R11 are independently selected from hydrogen and R9; R7 is selected from C1-4 alkyl, C3-5 cycloalkyl and C3-5 heterocycloalkyl; wherein said alkyl, cycloalkyl or heterocycloalkyl of R7 are optionally substituted with 1 to 3 radicals independently selected from halo, cyano, hydroxyl, C1-4 alkyl, halo-substituted C1-4 alkyl, C1-4 alkoxy and C1-4 halo alkoxy -replaced; or R7 is hydrogen; and N-oxide derivatives, tautomers and pharmaceutically acceptable salts and solvates (for example, hydrates) of said compoundsUn compuesto de Fórmula I: **Fórmula** en la que: Y se selecciona entre N y CR6; R1 es -CH2CHMeNH(CO)OMe; R2, R3, R5 y R6 se seleccionan independientemente entre hidrógeno, halo, ciano, alquilo C1-4, alquilo C1-4 halo-sustituido, alcoxi C1-4 y alcoxi C1-4 halo-sustituido; con la salvedad de que cuando R5 es flúor, R3 y R6 no son ambos hidrógeno; R4 se selecciona entre -R9 y -NR10R11; en donde R9 se selecciona entre alquilo C1-6, cicloalquilo C3-8, heterocicloalquilo C3-8, arilo y heteroarilo; en donde dichos alquilo, cicloalquilo, heterocicloalquilo, arilo o heteroarilo de R9 están opcionalmente sustituidos con 1 a 3 radicales seleccionados independientemente entre halo, ciano, alquilo C1-4, alquilo C1-4 halo-sustituido, alcoxi C1
来源网站:
中国工程科技知识中心
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