Compound of formula I: ** Formula ** in which: R1 is: phenyl substituted in the 4-position with methyl or halo and optionally substituted in the 2-position with halo: R2 is: hydrogen or C1-6 alkyl, R3 is: C1-6 alkyl, hydroxyalkyl-C1-6, alkoxy-C1-6-alkyl-C1-6, haloalkyl-C1-6, cycloalkyl-C3-7, heteroaryl, heterocyclyl, heterocyclyl-C1-6 alkyl, or cycloalkyl -C3-7-C1-6 alkyl, or R2 and R3 together form a cycloalkyl-C3-7, R4 is: hydrogen, C1-6 alkyl, cycloalkyl-C3-7, cycloalkyl-C3-7-alkyl-C1 -6 or pyrimidinyl, R 5 is: C 1-6 alkyl, C 1-6 alkoxy, C 3-7 cycloalkyl, C 1-6 alkoxy-C 1-6 alkyl, amino-C 1-6 alkyl, amino, optionally substituted oxetanyl twice with C1-6 alkyl, phenyl optionally substituted once or twice with a group or groups independently selected from C1-6 alkyl, halo, C1-6 haloalkyl and C1-6 alkoxy, optionally substituted thienyl once or twice with a group or groups independently selected from C1-alkyl -6 yalkoxy-C1-6； furanyl optionally substituted once or twice with C1-6 alkyl, thiazolyl optionally substituted once or twice with C1-6 alkyl, oxazolyl optionally substituted once or twice with C1-6 alkyl, isoxazolyls optionally substituted once or twice with a group or groups independently selected from C1-6alkyl and phenyl； pyrazolyl optionally substituted once or twice with C1-6 alkyl； thiadiazolyl optionally substituted once with C1-6 alkyl； tetrahydropyranyl, morpholinyl, piperidinyl optionally substituted with C1-6alkyl or acetyl, pyrazinyl, or pyridinyl optionally substituted once or twice with C1-6alkyl, and R6, R7 and R8 are: hydrogen.Compuesto de fórmula I:**Fórmnula** en las que: R1 es: fenilo sustituido en la posición 4 con metilo o halo y sustituido opcionalmente en la posición 2 con halo:R2 es: hidrógeno o alquilo C1-6, R3 es: alquilo-C1-6, hidroxialquilo-C1-6, alcoxi-C1-6-alquilo-C1-6, haloalquilo-C1-6, cicloalquilo-C3-7, heteroarilo,heterociclilo, heterociclil-alquilo-C1-6, o cicloalquil-C3-7-alquilo-C1-6, o R2 y R3 conjuntamente forman un cicloa
