GOBBI, LUCA,RODRIGUEZ SARMIENTO, ROSA MARÍA,WICHMANN, JUERGEN
申请号：
ES11727156
公开号：
ES2508170T3
申请日:
2011.06.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
compound of the formula (I) ** Formula ** in which X is O or S； Y is -C (O) - or -S (O) 2-； A is a single bond or a double bond, with the proviso that if X is S, then A is a double bond； R 1 is hydrogen, C 1-7 alkyl, C 1-7 haloalkyl, C 2-7 alkenyl, C 2-7 alkynyl, cycloalkyl, heterocycloalkyl, aryl, aryl fused with a heterocycloalkyl, heteroaryl, -N (R 6) 2, said C 1-7 alkyl , C1-7 haloalkyl, C2-7 alkenyl, C2-7 alkynyl are optionally substituted one to three times by substituents independently selected from the group consisting of cyano, cycloalkyl, heterocycloalkyl, aryl, aryl fused with a heterocycloalkyl, heteroaryl, - C (O) N (R6) 2, -N (R6) 2, -NH (CO) -C 1-7 alkyl, hydroxy, C 1-7 alkoxy, C 1-7 haloalkoxy, oxo and -S (O) 2 R7 and said cycloalkyl, heterocycloalkyl, aryl, aryl fused with a heterocycloalkyl and heteroaryl are optionally substituted one to three times by independent R4； R2, R3 are independently hydrogen, halogen, C1-7 alkyl, C1-7 haloalkyl, hydroxy, C1-7 alkoxy or C1-7 haloalkoxy； R4 is halogen, cyano, C1-7 alkyl, C1-7 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, aryl fused with a heterocycloalkyl, heteroaryl, -C (O) N (R6) 2, -N (R6) 2, -NH (CO) -C 1-7 alkyl, hydroxy, C 1-7 alkoxy, C 1-7 haloalkoxy, oxo, -S (O) 2 R 7 or C 1-7 alkyl substituted one to three times by substituents independently selected from the group consisting of cyano, hydroxy, C1-7 alkoxy and C1-7 haloalkoxy, said cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted one to three times by independent R5； R5 is halogen, cyano, C1-7 alkyl, C1-7 haloalkyl, hydroxy, C1-7 alkoxy, C1-7 haloalkoxy or oxo； R6 is hydrogen or C1-7 alkyl； R7 is hydrogen, C1-7 alkyl or aryl, said aryl is optionally substituted one to three times by independent R5； and pharmaceutically acceptable salts and esters thereof.compuesto de la fórmula (I) **Fórmula** en la que X es O o S； Y es -C(O)- o -S(O)2-； A es un enlace sencillo o un doble enlace, con la condición de que si X es S, ento
