1. This application describes the pyridan derivatives and pharmaceutically acceptable salts believed to interact with quinasa (Btk) of the thyroid gland in Broughton. Therefore, pyridine is effective in the treatment of autoimmune disorders, flammable diseases, allergic diseases, respiratory diseases such as asthma and COPD,Rejection of transplants, cancers, such as blood germs or solid tumors. 1. Claim 1: a formula compound (1),or a pharmaceutically acceptable salt thereof, wherein, R¹ is hydrogen, C₁₋₆ alkyl optionally substituted by hydroxyl； R² is hydrogen or halogen； R³ is hydrogen or halogen； R⁴ is hydrogen； R⁵ is hydrogen or halogen； or R⁴ and R⁵ are linked together and represent a bond, -CH₂-,-CH₂-CH₂-,-CH=CH---CH = CH-CH₂-；-CH₂-CH = CH-；or -CH₂-CH₂-CH₂-；R⁶ and R⁷ each independently represent H, C₁₋₆ alkyl optionally substituted by hydroxyl, C₃₋₆ cycloalkyl optionally substituted by halogen or hydroxyl, or halogen； R⁸,R8313,R, R, R¹⁰ and R¹¹ each independently represent H, or C₁₋₆ alkyl optionally substituted by C₁₋₆ alkoxy or any two of R⁸,R8313,R, R, R¹⁰ and R¹¹ together with the carbon atom to which they are attached can form a 3-6 membered saturated carbocyclic ring； R¹² is hydrogen or C₁₋₆ alkyl optionally substituted by halogen or C₁₋₆ alkoxy；Or anyone between R1 and r8322,R8313,R. R, R, r83041 or R1, together with the atoms to which they are attached, can form a periodic ring of 4, 5, 6 or 7 members, which can be optionally replaced by halogen, cyanogen, hydroxy, c833183226 tar or alcocilo c832183131；n is 0 or 1； and R¹³ is C₂₋₆ alkenyl optionally substituted by C₁₋₆ alkyl,e. Alcoxyl c83218c83316o n, n-di-alkylamine c832188326；C₂₋₆ alkynyl optionally substituted by C₁₋₆ alkyl or C₁₋₆ alkoxy；or C₂₋₆ alkylenyl oxide optionally substituted by C₁₋₆ alkyl.La presente solicitud describe derivados de amino pirimidina y sales farmacéuticamente aceptables de los mismos que parecen interactuar con la tirosina quinasa de Bruton (Btk). En consecuencia, las amino
