Referred to a compound of the formula [I -], B [I -], or [- C], wherein R1 is the formula (1), where A1A is c1-4 alkyl, r1b is c1-4 alkyl, or trifluoromethyl, and r1c is c1-4 alkyl,Fluoroalquilo c1-4 alkoxy, c1-4 alkoxy, or c1-4 alkyl c1-4 or the formula (2), where n is 1, 2, 3, 4 or 5, and R1D is Fluorine, c1-4 alkyl, fluoroalquilo c1-4 alkoxy, c1-4,C1-4 alkyl or alkoxy C1 - 4. R2 is Hydrogen or alkyl of C1 - 4. R3 is Hydrogen, halogen, alkyl or alkoxy C1 C1 - 4 - 4.R4 is the formula (3), where R4A is Hydrogen, alkyl or alkoxy C1 C1 - 4 - 4, or the formula (4), where R1 is alkyl R5 R6 - 6, 6 - C1 C3 alkyl, cycloalkyl - 5, c1-4 alkyl or alkoxy C1 - 4.X is CH2 or, provided that, when R2 in the formula (i-a) is c1-4 alkyl, then R3 is Hydrogen.This is composed of a hidroxitriazina and has an Inhibitory activity on microsomal prostaglandin e2 synthase (mpges-1) - 1, and is useful for the Prevention or treatment of PainGlaucoma, rheumatism, Osteoarthritis, Systemic Scleroderma and \/ OR colorectal cancer including cancer, among others.Referido a un compuesto de la formula [I-a], [I-b], o [I-c], caracterizado porque R1 es la formula (1), en donde R1a es alquilo C1-4 R1b es alquilo C1-4, o trifluorometilo, y R1c es alquilo C1-4, fluoroalquilo C1-4, alcoxi C1-4, o alcoxi C1-4-alquilo C1-4 o la formula (2), en donde n es 1, 2, 3, 4 o 5, y R1d es fluoro, alquilo C1-4, fluoroalquilo C1-4, alcoxi C1-4, o alcoxi C1-4-alquilo C1-4. R2 es hidrogeno o alquilo C1-4. R3 es hidrogeno, halogeno, alquilo C1-4, o alcoxi C1-4. R4 es la formula (3), en donde R4a es hidrogeno, alquilo C1-4 o alcoxi C1-4, o la formula (4), en donde R5 es alquilo C1-6, R6 es alquilo C1-6, cicloalquilo C3-5, o alcoxi C1-4-alquilo C1-4. X es CH2 u O, siempre que, cuando R2 en la formula (I-a) es alquilo C1-4, entonces R3 sea hidrogeno. Este, es un compuesto de hidroxitriazina y tiene una actividad inhibidora sobre la prostaglandina microsomal E2 sintasa-1 (mPGES-1), y es de utilidad para la prevencion o el trat
