您的位置: 首页 > 农业专利 > 详情页

Derivatives 1¿ (piperazin¿1¿il) ¿2¿ ([1,2,4] triazol¿1¿il) ¿ethanone
专利权人:
Idorsia Pharmaceuticals Ltd
发明人:
CAROFF, Eva,MEYER, Emmanuel
申请号:
ES14744031
公开号:
ES2671323T3
申请日:
2014.07.21
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of Formula (I) ** Formula ** in which ** Formula ** X represents N or CH; Y represents N or CR6; R1 represents (C1-4) alkyl; cycloalkyl (C3-6); (C1-4) alkoxy; cycloalkoxy (C3-6); fluoroalkyl (C1-3); fluoroalkoxy (C1-3); halogen; cyano; (C1-2) alkoxy-(C2-3) alkoxy; (C1-3) alkyl which is mono-substituted with -NR7R8; (C2-3) alkoxy which is mono-substituted with -NR7R8; heterocyclyl, wherein the heterocyclyl is a 4 to 6 membered monocyclic saturated ring containing one or two heteroatoms independently selected from nitrogen and oxygen and wherein said heterocyclyl is unsubstituted or mono-substituted with C1-2 alkyl ); or heterocyclyloxy, wherein the heterocyclyl is a 4- to 6-membered monocyclic saturated ring containing an oxygen atom; R2 represents hydrogen, (C1-4) alkoxy or fluorine; R3 represents hydrogen or methyl; R4 represents (C1-4) alkyl, or (C1-2) alkyl that is mono-substituted with -NR7R8; R5 represents (C1-4) alkyl; R6 represents hydrogen, (C1-4) alkyl or fluorine; or R1 and R6 form, together with the carbon atoms to which they are attached, a 5- or 6-membered heterocyclic ring, in which the remainder necessary to complete said heterocyclic ring is selected from -OCH2CH2- *, -OCH2O- * , -OCH2CH2CH2- * and -OCH2CH2O- *, in which the asterisks indicate the bond that is linked to the carbon atom carrying R6; R7 represents (C1-2) alkyl; and R8 represents (C1-2) alkyl; or a pharmaceutically acceptable salt thereof.Un compuesto de Fórmula (I) **Fórmula** en la que**Fórmula** X representa N o CH; Y representa N o CR6; R1 representa alquilo (C1-4); cicloalquilo (C3-6); alcoxi (C1-4); cicloalcoxi (C3-6); fluoroalquilo (C1-3); fluoroalcoxi (C1-3); halógeno; ciano; alcoxi (C1-2) - alcoxi (C2-3); alquilo (C1-3) que está mono-sustituido con -NR7R8; alcoxi (C2-3) que está mono-sustituido con -NR7R8; heterociclilo, en el que el heterociclilo es un anillo saturado mono- cíclico de 4 a 6 miembros que contiene uno o dos heteroátomos independientemente seleccionado
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充