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Dihydrobenzoindazoles
专利权人:
MERCK SHARP & DOHME B.V.
发明人:
TIMMERS, CORNELIS MARIUS,LOOZEN, HUBERT JAN JOZEF
申请号:
ES10742796
公开号:
ES2497165T3
申请日:
2010.07.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A dihydrobenzoindazole compound according to formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein R1 is phenyl, optionally substituted with halogen, nitro, (C1-6) alkyl, (C2-5) alkenyl 6), (C1-6) alkoxy, (C2-5) heteroaryl, (C3-6) cycloalkyl; or R1 is heteroaryl (C2-5), optionally condensed with a benzo group and optionally substituted in the heteroaryl or benzo group with halogen or a (C1-4) alkyl group; or R1 is heterocycloalkyl (C2-5) or heterocycloalkenyl (C2-5), both optionally substituted with one or more fluorine, (C1-2) alkyl groups or (C1-3) alkoxy groups R2 is a (C1-6 alkyl group ), (C2-6) alkenyl, (C2-6) alkynyl, (C1-6) alkoxy or (C1-4) alkylsulfonylamino, all alkyl groups being optionally substituted with one or more hydroxyl or fluorine groups; or R2 is heteroaryl (C2-5), R5-carbonylamino or R5-aminocarbonyl R3 is (C1-6) alkoxy or hydroxyl; R4 is (di) [(C1-6) alkyl] amino; or R4 is pyrrolidin-1-yl, optionally substituted with one or more (C1-2) alkyl groups; or R4 is 1,4-diazacycloheptyl, optionally substituted in the 4-position nitrogen with alkyl (C1-6) carbonyl or cycloalkyl (C3-6) carbonyl; or R4 is R5 is heteroaryl (C2-5) or alkyl (C1-6), both optionally substituted with one or more hydroxyl groups or halogens; or R5 is heterocycloalkyl (C2-5) alkyl (C1-4), the heterocycloalkyl group being optionally substituted with (C1-4) alkyl or (di) [C1-4 alkyl )] amino (C1-4) alkyl; and R6 is (C1-6) alkyl.Un compuesto de dihidrobenzoindazol de acuerdo con la fórmula I:**Fórmula** o una de sus sales farmacéuticamente aceptable, en la que R1 es fenilo, opcionalmente sustituido con halógeno, nitro, alquilo(C1-6), alquenilo(C2-5 6), alcoxi(C1-6), heteroarilo(C2-5), cicloalquilo(C3-6); o R1 es heteroarilo (C2-5), opcionalmente condensado con un grupo benzo y opcionalmente sustituido en el grupo heteroarilo o benzo con halógeno o un grupo alquilo(C1-4); o R1 es heterocicloalquilo (C2-5) o heterocicloalquenilo(C2-5), ambos opcionalmente sus
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