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Aminopyrimidine derivatives as modulators of LRRK2
专利权人:
Genentech; Inc.
发明人:
BAKER-GLENN, Charles,CHAMBERS, Mark,CHAN, Bryan K.,CHEN, Huifen,ESTRADA, Anthony,SHORE, David,SWEENEY, Zachary
申请号:
ES12797826
公开号:
ES2638595T3
申请日:
2012.11.28
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula I: ** Formula ** or pharmaceutically acceptable salts thereof, wherein: m is from 0 to 3; X is: -NRa-; -OR-; or -S (O) r- where r is from 0 to 2 and Ra is hydrogen or C1-6 alkyl; R1 is: C1-6 alkyl; R2 is: halo; C1-6 alkoxy; cyano; C2-6 alkynyl; C2-6 alkenyl; halo C1-6 alkyl; C1-6 haloalkoxy; C3-6 cycloalkyl wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl; C3-6 cycloalkyl-C1-6 alkyl wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl; tetrahydrofuranyl; tetrahydrofuranoyl-C 1-6 alkyl; acetyl; oxetanyl; or oxetan-C1-6 alkyl; R3 and R4 each independently are: halo; C1-6 alkyl; C1-6 alkoxy; C3-6 cycloalkyloxy; halo C1-6 alkyl; or haloC 1-6 alkoxy; or R3 and R4 together with the atoms to which they are attached can form a five or six member ring that optionally includes one or two heteroatoms each independently selected from O, N and S, the ring being optionally substituted one or more times with R6; R5 is: C1-6 alkyl sulfonyl; or cyano; and R6 is: C1-6 alkyl; halo; halo C1-6 alkyl; or oxo.Un compuesto de fórmula I:**Fórmula** o sales farmacéuticamente aceptables de los mismos, en donde: m es de 0 a 3; X es: -NRa-; -O-; o -S(O)r- en donde r es de 0 a 2 y Ra es hidrógeno o alquilo C1-6; R1 es: alquilo C1-6; R2 es: halo; alcoxi C1-6; ciano; alquinilo C2-6; alquenilo C2-6; halo-alquilo C1-6; halo-alcoxi C1-6; cicloalquilo C3-6 en donde la porción de cicloalquilo C3-6 está opcionalmente sustituida con alquilo C1-6; cicloalquil C3-6-alquilo C1-6 en donde la porción de cicloalquilo C3-6 está opcionalmente sustituida con alquilo C1-6; tetrahidrofuranilo; tetrahidrofuranoil-alquilo C1-6; acetilo; oxetanilo; u oxetan-alquilo C1-6; R3 y R4 cada uno independientemente son: halo; alquilo C1-6; alcoxi C1-6; cicloalquiloxi C3-6; halo-alquilo C1-6; o halo-alcoxi C1-6; o R3 y R4 junto con los átomos a los que están unidos pueden formar un anillo de cinco o seis miembros que incluye opcionalmente uno o dos hete
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