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专利权人:
MEDIVIR UK LIMITED
发明人:
URSZULA GRABOWSKA,SUSANA AYESA,ELLEN HEWITT,DANIEL JOENSON,PIA KAHNBERG,BJOERN KLASSON,STINA LUNDGREN,DANIEL WIKTELIUS,JAN TEJBRANT
申请号:
MX2012014830
公开号:
MX2012014830A
申请日:
2011.06.16
申请国别(地区):
MX
年份:
2013
代理人:
摘要:
Compounds of the formula (I) wherein R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl R3 is a C5-C10 alkyl, optionally substituted with 1-3 substituents independently selected from halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy or R3 is a C2-C4alkyl chain with at least 2 chloro or 3 fluoro substituents or R3 is C3-C7cycloalkylmethyl, optionally substituted with 1-3 substituents independently selected from C1-C4alkyl, halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy R4 is C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylamino, C1- C6dialkylamino or R4 is Het or Carbocyclyl, either of which is optionally substituted with 1-3 substituents n is 1, 2 or 3 for the use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.Se describen compuestos de la fórmula (I), en donde R2a y R2b son independientemente H, halo, C1-C4alquilo, C1-C4haloalquilo o C1-C4alcoxi, o R2a y R2b junto con el átomo de carbono al cual se adhieren forman un C3-C6cicloalquilo R3 es un C5-C10 alquilo, opcionalmente sustituido con 1 a 3 sustituyentes seleccionados independientemente de halo, C1-C4haloalquilo, C1-C4alcoxi, C1-C4haloalcoxi o R3 es una cadena C2-C4alquilo con al menos 2 sustituyentes cloro o 3 fluoro o R3 es C3-C7cicloalquilmetilo opcionalmente sustituido con 1 a 3 sustituyentes seleccionados independientemente de C1-C4alquilo, halo, C1-C4haloalq
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