ORTEGA MUNOZ, ALBERTO,CASTRO-PALOMINO LARIA, JULIO,FYPE, MATTHEW COLIN THOR
申请号：
MX2012012111
公开号：
MX2012012111A
申请日:
2011.04.19
申请国别(地区):
MX
年份:
2013
代理人:
摘要：
The present invention relates to a compound of Formula 1, wherein: (A) is heteroaryl or aryl each (Α), if present, is independently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (Α) is substituted with 0, 1, 2, or 3 substituents independently chosen from halo, haloalkyl, haloalkoxy, aryl, arylalkoxy, alkyl, alkoxy, amido, -CH2C(=0)NH2, heteroaryl, cyano, sulfonyl, and sulfinyl X is 0, 1, 2, or 3 (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B) (Z) is -NH- (L) is chosen from a single bond, -CH2-, -CH2CH2-, -CH2CH2CH2-, and -CH2CH2CH2CH2- and (D) is an aliphatic carbocyclic group or benzocycloalkyl, wherein said aliphatic carbocyclic group or said benzocycloalkyl has 0, 1, 2, or 3 substituents independently chosen from - NH2, -NH(C1-C6 alkyl), -N(C1-C6 alkyl)(C1-C6 alkyl), alkyl, halo, amido, cyano, alkoxy, haloalkyl, and haloalkoxy. (A)X-(A)-(B)-(Z)-(L)-(D) formula (I) The compounds of the invention show activity for inhibiting LSD1, which makes them useful in the treatment or prevention of diseases such as cancer.La presente invención se relaciona con un compuesto de la Fórmula 1, donde: (A) es heteroarilo o arilo cada (A´), si está presente, es indistintamente seleccionado a partir de arilo, arilalcoxilo, arilalquilo, heterociclilo, ariloxilo, halo, alcoxilo, haloalquilo, cicloalquilo, haloalcoxilo, y ciano, donde cada (A´) es sustituido con 0, 1, 2, o 3 sustitutos indistintamente seleccionados a partir de halo, haloalquilo, haloalcoxilo, arilo, arilalcoxilo, alquilo, alcoxilo, amido, -CH2C(=O)NH2, heteroarilo, ciano, sulfonilo y sulfinilo X es 0, 1, 2, o 3 (B) es un anillo de ciclopropilo, donde (A) y (Z) covalentemente se unen a diferentes átomos de carbono de (B) (Z) es -NH (L) se selecciona de un enlace individual, -CH2-, -CH2CH2-, -CH2CH2CH2-, y -CH2CH2CH2CH2- y (D) es un grupo carbocíclico alifático o benzocicloalqu
