Alberto Ortega Muñoz,Julio Castro-Palomino Laria,Matthew Colin Thor Fyfe
申请号：
US14228083
公开号：
US09149447B2
申请日:
2014.03.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a compound of Formula 1, wherein: (A) is heteroaryl or aryl each (A′), if present, is independently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2, or 3 substituents independently chosen from halo, haloalkyl, haloalkoxy, aryl, arylalkoxy, alkyl, alkoxy, amido, —CH2C(═0)NH2, heteroaryl, cyano, sulfonyl, and sulfinyl X is 0, 1, 2, or 3 (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B) (Z) is —NH— (L) is chosen from a single bond, —CH2—, —CH2CH2—, —CH2CH2CH2—, and —CH2CH2CH2CH2— and (D) is an aliphatic carbocyclic group or benzocycloalkyl, wherein said aliphatic carbocyclic group or said benzocycloalkyl has 0, 1, 2, or 3 substituents independently chosen from —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), alkyl, halo, amido, cyano, alkoxy, haloalkyl, and haloalkoxy. (A′)X-(A)-(B)—(Z)-(L)-(D) formula (I) The compounds of the invention show activity for inhibiting LSD1, which makes them useful in the treatment or prevention of diseases such as cancer.
