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DERIVATIVES OF �? CIDO BEZOXAZEPIN-OXI-ACETIC AS A PPAR-DELTA AGONIST USED TO INCREASE HDL-C, DECREASE THE LDL-C AND DECREASE CHOLESTEROL.
专利权人:
JANSSEN PHARMACEUTICA NV
发明人:
GEE-HONG, KUO,ZHANG, YAN,SHEN, LAN,LU, SONGFENG,DEMAREST, KEITH T.,PELTON, PATRICIA
申请号:
ES07760766
公开号:
ES2375754T3
申请日:
2007.04.17
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of Formula (I) Formula (I) in which: X is a covalent bond, O or S; R1 and R2 are independently selected from the group consisting of H, C1-8 alkyl and substituted C1-8 alkyl, or R1, R2 and the carbon atom to which they are attached can form C3-7 cycloalkyl; R3 is H; R4 and R5 are independently selected from the group consisting of H, halo, C1-8 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, C3-7 cycloalkyloxy-C1-4 alkyl, C1-6 alkoxy -C1-4 alkyl, C6-10 aryl, heteroaryl, C1-4 alkyl substituted halo, C1-4 alkyl substituted, C1-4 alkyl substituted with C6-10 aryl, substituted C1-4 cyano alkyl and C1-4 hydroxy alkyl replaced; R6 and R7 are independently selected from the group consisting of H, halo, C1-3 alkyl, C1-3 alkyl substituted halo, C1-3 alkoxy and C1-3 alkoxy halo substituted; n is 1; and Q is selected from the group consisting of and enantiomers, diastereomers, tautomers, solvates or pharmaceutically acceptable salts thereof.Un compuesto de Fórmula (I) Fórmula (I) en la que: X es un enlace covalente, O o S; R1 y R2 se seleccionan independientemente entre el grupo que consiste en H, alquilo C1-8 y alquilo C1-8 sustituido, o R1, R2 y el átomo de carbono al que están unidos pueden formar cicloalquilo C3-7; R3 es H; R4 y R5 se seleccionan independientemente entre el grupo que consiste en H, halo, alquilo C1-8, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-4, cicloalquiloxi C3-7-alquilo C1-4, alcoxi C1-6-alquilo C1-4, arilo C6-10, heteroarilo, alquilo C1-4 halo sustituido, alquilo C1-4 amino sustituido, alquilo C1-4 sustituido con arilo C6-10, alquilo C1-4 ciano sustituido y alquilo C1-4 hidroxi sustituido; R6 y R7 se seleccionan independientemente entre el grupo que consiste en H, halo, alquilo C1-3, alquilo C1-3 halo sustituido, alcoxi C1-3 y alcoxi C1-3 halo sustituido; n es 1; y Q se selecciona entre el grupo que consiste en y enantiómeros, diastereómeros, tautómeros, solvatos o sales farmacéuticamente aceptables del mismo.
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