DIDIUK, Mary Theresa,DOW, Robert Lee,GRIFFITH, David Andrew
申请号：
ES11768163
公开号：
ES2602111T3
申请日:
2011.09.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof； wherein R1 is (C1-C6) alkyl, (C3-5 C7) cycloalkyl, tetrahydrofuranyl or oxetanyl； wherein said (C1-C6) alkyl is optionally substituted with 1 to 3 substituents independently selected from (C1-C3) alkoxy, hydroxy, fluoro, phenyl, tetrahydrofuranyl or oxetanyl； R2 is hydrogen, halo, (C1-C3) alkyl or cyano； R3 are each independently hydrogen or (C1-C3) alkyl； L is a direct bond or a (C1-C6) alkylene in which a carbon of the (C1-C6) alkylene is optionally replaced by -C (O) -, -C (O) NH-, -NHC (O) - , -O-, -S-, NH or N-C1-C3 alkyl； Z is CH2 or O； A1 and A2 are each independently aryl (C6-C10), 5 to 12 membered heteroaryl or condensed 8 to 12 membered heterocyclic aryl； wherein said aryl (C6-C10), 5-12 membered heteroaryl or condensed heterocyclic aryl of 8 to 12 members are each optionally substituted with one to three substituents independently selected from (C1-C3) alkyl, (C1-) alkoxy C3), halo, amino, (C1-C3) alkylamino, di-C1-C3 alkylamino, hydroxy, cyano and amido in which the alkyl portion of the (C1-C3) alkyl, (C1-C3) alkoxy, alkylamino (C1-C3) and di-alkylamino (C1-C3) is optionally substituted with one to five fluoro； and wherein one of A1 or A2 is substituted with CO2R4, (C1-C6) CO2R4, tetrazolyl or tetrazolyl (C1-C6)； and R4 is (C1-C8) alkyl, (C3-C8) cycloalkyl or (C1-C6) alkyl (C3-C8) alkyl； or a pharmaceutically acceptable salt thereof.Un compuesto de Fórmula (I)**Fórmula** o una sal farmacéuticamente aceptable del mismo； en la que R1 es alquilo (C1-C6), cicloalquilo (C3-5 C7), tetrahidrofuranilo o oxetanilo； en el que dicho alquilo (C1-C6) está opcionalmente sustituido con 1 a 3 sustituyentes seleccionados independientemente de alcoxi (C1-C3), hidroxi, fluoro, fenilo, tetrahidrofuranilo u oxetanilo； R2 es hidrógeno, halo, alquilo (C1-C3) o ciano； R3 son cada uno independientemente hidrógeno o alquilo (C1-C3)； L es un enlace directo o un alquileno (C1-C6) en el que un car
