A compound of formula IV: ** Formula ** or pharmaceutically acceptable salts thereof； wherein R4 is H or C1-C6 alkyl； each R5 is independently selected in each presence from the group consisting of CH3, C1-C6 alkoxy, halo, -CN, -NO2, -C1-C6 alkyl halo, C1-C6 dihaloalkyl and C1-C6 -trhaloalkyl； R10 is OH, halo, C1-C6 alkyl, (C1-C6 alkyl) -OH, -C1-C6-chloroalkyl, C1-C6-dichlororalkyl, -C1-C6-chloroalkyl, -C1-C6-fluoroalkyl, -C1-C6-alkyl-alkyl, -C1-C6trifluoroalkyl, C1-C6 heteroalkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, aryl, heteroaryl, - (C1-C4 alkyl) - (C3-C10 cycloalkyl), - (C1-C4 alkyl) - (heterocycloalkyl C3-C10), - (C1-C4 alkyl) - (aryl) or - (C1-C4 alkyl) - (heteroaryl), and wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, the aryl or heteroaryl ring is optionally substituted with 1-5 substituents selected from R2； R11 is a C1-C3 alkylene or bond, wherein C1-C3 alkylene is optionally substituted with 1-3 substituents selected from R2； R2 is independently selected in each presence from the group consisting of halo, -CN, -NO2, -C1-C6 alkyl, -C1-C6 alkoxy, -C1-C6 fluoroalkyl, -C1-C6 heteroalkyl, C (O) - ( C1-C6 alkyl) and C (O) - (C1-C6 alkoxy)； w is 0, 1 or 2； each presence of x is independently selected from the group consisting of 0, 1, 2, 3 and 4； each presence of y is independently selected from the group consisting of 1, 2, and 3； and each presence of z is independently selected from the group consisting of 0, 1, 2, and 3.Un compuesto de fórmula IV: **Fórmula** o sales farmacéuticamente aceptables del mismo； en donde R4 es H o alquilo C1-C6； cada R5 se selecciona independientemente en cada presencia del grupo que consiste en CH3, alcoxi C1-C6, halo, -CN, -NO2, -haloalquilo C1-C6, -dihaloalquilo C1-C6 y -trihaloalquilo C1-C6； R10 es OH, halo, alquilo C1-C6, (alquil C1-C6)-OH, -cloroalquilo C1-C6, -diclororalquilo C1-C6, -tricloroalquilo C1-C6, -fluoroalquilo C1-C6, -difluoroalquilo C1-C6, -trifluoroalquilo C1-C6, heteroalquilo C1-C6, cicl
