SPRINGER, John Robert,DEVADAS, Balekudru,GARLAND, Danny James,GRAPPERHAUS, Margaret Lanahan,HAN, Seungil,HOCKERMAN, Susan Landis,HUGHES, Robert Owen,SAIAH, Eddine,SCHNUTE, Mark Edward,SELNESS, Shaun R
申请号：
ES13792494
公开号：
ES2625944T3
申请日:
2013.11.01
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound having Formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, wherein A is arylene, 5 membered heteroarylene or 6 membered heteroarylene, optionally substituted with one, two, three or four R6 selected independently from the group consisting of (C1-C4) alkyl, halo (C1-C4) alkyl, halo, hydroxy and (C1-C4) alkoxy； X is O, S, C (>； = O), C (OR4) or C (R5a) (R5b)； W is aryl, 5-membered heteroaryl or 6-membered heteroaryl, optionally substituted with one, two, three, four or five R7 independently selected from the group consisting of (C1-C4) alkyl, halo (C1-C4) alkyl, cycloalkyl (C3-C6), saturated 4-6 membered heterocycle, halo, hydroxy, hydroxyalkyl (C1-C4), alkoxy (C1-C4), hydroxyalkoxy (C2-C4) and haloalkoxy (C1-C4)； R1 is a 4-8 membered nitrogen containing heterocycle substituted on said nitrogen with R and further, optionally substituted with one, two, three, four or five substituents independently selected from the group consisting of (C1-C4) alkyl, haloalkyl (C1-C4), halo, hydroxyl and (C1-C4) alkoxy； R is cyano, cyanoalkyl (C1-C3), R2a, R2b, R3a, R3b and R4 are independently selected from the group consisting of hydrogen or (C1-C3) alkyl； R5a and R5b are independently selected from the group consisting of hydrogen, halo and (C1-C3) alkyl； Ra is hydrogen, halo, cyano, (C1-C6) alkoxy, haloalkoxy (C1-C6), alkylthio (C1-C4), alkylsulfonyl (C1-C4) or alkyl (C1-C6) optionally substituted with halo, hydroxyl, alkoxy (C1-C6) or haloalkoxy (C1-C6)； Rb and Rc are independently selected from the group consisting of hydrogen, halo, cyano, (C1-C6) alkoxy, haloalkoxy (C1-C6), cycloalkyl (C3-C6), C (>； = O) Rd and alkyl (C1 -C6) optionally substituted with one, two or three Rf independently selected from the group consisting of halo, hydroxyl, N (Re) 2, alkoxy (C1-C6), haloalkoxy (C1-C6) and aryl； or Rb and Rc taken together with the carbon to which they are attached form a 4-7 membered carbocycle or heterocycle optionally substituted with one,
