BRESLIN, HENRY J.,CAI, CHAOZHONG,HE, WEI,KAVASH, ROBERT W.
申请号：
ES10182349
公开号：
ES2428008T3
申请日:
2005.03.14
申请国别(地区):
ES
年份:
2013
代理人:
摘要：
A compound of Formula (I) ** ** Formula wherein: R1 is selected from the group consisting of hydrogen, C1-6 alkyl, cycloalkyl, heterocyclyl, aryl (C1-6) alkyl and heteroaryl (C1-6) wherein when R1 is phenyl- (1-6C) alkyl, phenyl is optionally fused to a heterocyclyl or cycloalkyl wherein when R1 is C1-2alkyl, said C1-2alkyl is optionally substituted with one to two substituents independently selected from the group consisting of C1-6alkoxy, aryl, cycloalkyl, heterocyclyl, hydroxy, cyano, amino, alkylamino C1-6, (C1-6alkyl) 2amino, trifluoromethyl, and carboxy and further, wherein when R1 is C3-6alkyl, said C3-6alkyl is optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkoxy, aryl, cycloalkyl, heterocyclyl, hydroxy, cyano, amino, C1-6alkylamino, (C1-6alkyl) 2amino, trifluoromethyl, and carboxy wherein the cycloalkyl and heterocyclyl of C1-2alkyl and C3-6 alkyl are optionally substituted with one to two substituents independently selected from the group consisting of C1-6alkyl, hydroxy (C1-6) alkyl, C1-6 alkoxy , hydroxy, cyano, amino, C1-6alkylamino, (C1-6alkyl) 2amino, trifluoromethyl, carboxy, arylalkoxycarbonyl (C1- 6), C1-6alkoxycarbonyl, aminocarbonyl, C1-6alkyl, (C1-6alkyl) 2aminocarbonilo and aminosulfonyl furthermore, wherein the cycloalkyl and heterocyclyl of R1 are optionally substituted with one to two substituents independently selected from the group consisting of C1-6 alkyl, hydroxyalkyl (C1-6), C1-6 alkoxy, hydroxy, cyano, amino , C1-6alkylamino, (C1-6alkyl) 2amino, trifluoromethyl, carboxy, arylalkoxycarbonyl (C1-6), C1-6 alkoxycarbonyl, aminocarbonyl, C1-6, (C1-6 alkyl) aminosulfonyl and 2aminocarbonilo further wherein the aryl and heteroaryl portion of aryl substituents R1 (1-6C) heteroaryl (1-6C) alkyl is optionally substituted with one to three R11 substituents independently selected from the group consisting of C1-6 alkyl hydroxy (C1-6) C1-6 alkoxy C6-10 aryl-alkyl (C1-6) C6-10 aryl (1
