compound or salt of the formula ** Formula ** wherein R1 and R2 are joined to form a pyrrolidine, piperidine or piperazine ring, or a piperazine ring fused to a phenyl, each of which is optionally substituted with 0 to 2 independently selected substituents of halogen, hydroxyl, amino, CONH2, C1-C2 alkyl and C1-C2 alkoxy； R3 and R4 are independently selected from hydrogen, C1-C4 alkyl and (C3-C7 cycloalkyl) C0-C2 alkyl； R9 is hydroxyl, amino, -COOH, -NR10R11, -OR12, -NR10SO2R11, - (C>； = O) OR10 or -CONR10R11； R10, R11 and R12 are independently hydrogen or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C3-C7 cycloalkyl) C0-C2 alkyl, (heterocycloalkyl) C0-C2 alkyl, (phenyl) C0 alkyl -C2 or (5-6 membered monocyclic heteroaryl) C0-C2 alkyl, each of which is substituted with 0 to 3 independently selected substituents of halogen, hydroxyl, oxo, C1-C2 alkyl, C1-C2 alkoxy, trifluoromethyl and trifluoromethoxy； R16 is 0 to 2 independently selected substituents of halogen, C1-C2 alkyl and C1-C2 alkoxy； M is hydrogen or methyl； and Z is a quinoline of the formula ** Formula **compuesto o sal de la fórmula **Fórmula** en donde R1 y R2 están unidos para formar un anillo de pirrolidina, piperidina o piperazina, o un anillo de piperazina condensado a un fenilo, cada uno de los cuales está opcionalmente sustituido con 0 a 2 sustituyentes independientemente elegidos de halógeno, hidroxilo, amino, CONH2, alquilo C1-C2 y alcoxi C1-C2； R3 y R4 se eligen independientemente de hidrógeno, alquilo C1-C4 y (cicloalquil C3-C7)alquilo C0-C2； R9 es hidroxilo, amino, -COOH, -NR10R11, -OR12, -NR10SO2R11, -(C>；=O)OR10 o -CONR10R11； R10, R11 y R12 son, independientemente, hidrógeno o alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, (cicloalquil C3-C7)alquilo C0-C2, (heterocicloalquil)alquilo C0-C2, (fenil)alquilo C0-C2 o (heteroarilo monocíclico de 5 a 6 miembros)alquilo C0-C2, cada uno de los cuales está sustituido con 0 a 3 sustituyentes independientemente elegidos de halógeno, hidroxilo, oxo,
